Bioactive phenolic compounds from a medicinal lichen, Usnea longissima

被引：61

作者：

Choudhary, MI ^{[1
]}

Azizuddin ^{[1
]}

Jalil, S ^{[1
]}

Atta-ur-Rahman ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 19期

关键词：

Usnea longissirna; lichen; Usneaceae; glutinol; longissiminone; anti-inflammatory; cytotoxicity;

D O I：

10.1016/j.phytochem.2005.06.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural products, longissiminone A (1) and longissiminone B (2), were isolated along with a known compound, glutinol (3), from a medicinal lichen, Usnea longissima. The structures of compounds 1 and 2 were determined with the help of spectroscopic studies. Compound 1 was found to possess potent anti-inflammatory activity in a cell-based contemporary assay. Cytotoxicity activity measured by cell viability assay showed 100% viability in the presence of 200 mu g/mL cone. of these compounds. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2346 / 2350

页数：5

共 15 条

[1]

Berridge M.V., 1996, BIOCHEMICA, V4, P15

[2] 2 PHENOLIC DERIVATIVES FROM EUPHORBIA-KANSUI [J].

DING, YL ;

JIA, ZJ .

PHYTOCHEMISTRY, 1992, 31 (04) :1435-1436

[3] Analgesic triterpenes from Sebastiania schottiana roots [J].

Gaertner, M ;

Müller, L ;

Roos, JF ;

Cani, G ;

Santos, ARS ;

Niero, R ;

Calixto, JB ;

Yunes, RA ;

Delle Monache, F ;

Cechinel, V .

PHYTOMEDICINE, 1999, 6 (01) :41-44

[4] TRITERPENES FROM MAYTENUS-HORRIDA [J].

GONZALEZ, AG ;

FERRO, EA ;

RAVELO, AG .

PHYTOCHEMISTRY, 1987, 26 (10) :2785-2788

[5] MONOHYDROXY TEREPHTHALIC AND 2,5-DIHYDROXY TEREPHTHALIC ACIDS, 2 UNUSUAL PHENOLICS ISOLATED FROM CENTAURIUM-ERYTHRAEA AND IDENTIFIED IN OTHER GENTIANACEAE MEMBERS [J].

HATJIMANOLI, M ;

FAVREBONVIN, J ;

KAOUADJI, M ;

MARIOTTE, AM .

JOURNAL OF NATURAL PRODUCTS, 1988, 51 (05) :977-980

[6]

HOBBS C, 1986, USNEAR HERBAL ANTIBI, P91

[7]

MACDONALD TM, 2002, PHARMACOEPIDEMIOLOGI, V11

[8] Evaluation of the antiviral and antimicrobial activities of triterpenes isolated from Euphorbia segetalis [J].

Madureira, AM ;

Ascenso, JR ;

Valdeira, L ;

Duarte, A ;

Frade, JP ;

Freitas, G ;

Ferreira, MJU .

NATURAL PRODUCT RESEARCH, 2003, 17 (05) :375-380

[9] Occurrence of usnic acid in Usnea laevis Nylander (lichenized ascomycetes) from the Venezuelan Andes [J].

Marcano, V ;

Rodriguez-Alcocer, V ;

Méndez, AM .

JOURNAL OF ETHNOPHARMACOLOGY, 1999, 66 (03) :343-346

[10] Nonsteroidal anti-inflammatory drugs, apoptosis, and colorectal adenomas [J].

Martin, C ;

Connelly, A ;

Keku, TO ;

Mountcastle, SB ;

Galanko, J ;

Woosley, JT ;

Schliebe, B ;

Lund, PK ;

Sandler, RS .

GASTROENTEROLOGY, 2002, 123 (06) :1770-1777

← 1 2 →