LDH-A promotes malignant behavior via activation of epithelial-to-mesenchymal transition in lung adenocarcinoma

被引:57
作者
Hou, Xiao-ming [1 ,2 ]
Yuan, Shu-qiao [3 ]
Zhao, Da [1 ]
Liu, Xiao-jun [1 ]
Wu, Xin-an [2 ,4 ]
机构
[1] Lanzhou Univ, Hosp 1, Dept Oncol, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China
[3] Lanzhou Univ, Hosp 1, Dept Med Lab, Lanzhou 730000, Gansu, Peoples R China
[4] Lanzhou Univ, Hosp 1, Dept Pharm, Lanzhou 730000, Gansu, Peoples R China
关键词
LACTATE-DEHYDROGENASE; CANCER; PROGRESSION; INHIBITION; METABOLISM;
D O I
10.1042/BSR20181476
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lactate dehydrogenase A (LDH-A) is a key enzyme during glycolysis, which increases the synthesis of related proteins and has elevated activity in cancer cells. The role of LDH-A in lung adenocarcinoma (LUAD) progression was investigated in the present study. Expression levels of LDH-A were assessed in LUAD samples, and the relationship between LDH-A expression status and the prognosis of LUAD patients was confirmed. The effect of LDH-A on proliferation, invasion, migration, and colony formation of cancer cells was assessed. We further determined the role of LDH-A in tumor growth in vivo by using xenograft LUAD tumor models. The potential mechanism of LDH-A promotion in LUAD progression was explored. LDH-A showed an abnormally high expression in LUAD, which is closely associated with poor prognosis in patients with LUAD. In in vitro experiments, silencing LDH-A expression in LUAD cells could effectively inhibit proliferation, invasion, migration, and colony formation of cancer cells. In in vivo experiments, tumor growth was markedly inhibited by LDH-A silencing in a xenograft model of LUAD. Notably, LDH-A could also promote tumor progression by regulating epithelial-mesenchymal transition (EMT)-related molecules. LDH-A can promote the malignant biological behaviors of LUAD cells, and thus can be a potential target for LUAD treatment.
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页数:10
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