The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder

被引:6
作者
Zhou, Cui-Hong [1 ,2 ]
Xue, Fen [1 ,2 ]
Shi, Qing-Qing [1 ]
Xue, Shan-Shan [1 ]
Zhang, Tian [1 ]
Ma, Xin-Xu [1 ]
Yu, Li-Sheng [3 ]
Liu, Chuang [4 ]
Wang, Hua-Ning [1 ,2 ]
Peng, Zheng-Wu [1 ]
机构
[1] Air Force Med Univ, Xijing Hosp, Dept Psychiat, Xian, Peoples R China
[2] Air Force Med Univ, Sch Publ Hlth, Shaanxi Key Lab Free Radical Biol & Med, Dept Toxicol,Minist Educ,Key Lab Hazard Assessmen, Xian, Peoples R China
[3] Shaanxi Prov Peoples Hosp, Dept Gen Med, Xian, Peoples R China
[4] Fourth Mil Med Univ, Xijing Hosp, Dept Obstet, Xian, Peoples R China
来源
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2022年 / 15卷
基金
中国国家自然科学基金;
关键词
electroacupuncture; post-traumatic stress disorder; lipidomics; hippocampus; prefrontal cortex; mouse model; MEMBRANE-LIPIDS; BIPOLAR DISORDER; FATTY-ACIDS; RAT MODEL; ANXIETY; PTSD; DEPRESSION; MEMORY; ACUPUNCTURE; METABOLISM;
D O I
10.3389/fnmol.2022.812479
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The neuroprotective effect of electroacupuncture (EA) treatment has been well studied; growing evidence suggests that changes in lipid composition may be involved in the pathogenesis of post-traumatic stress disorder (PTSD) and may be a target for treatment. However, the influence of early EA intervention on brain lipid composition in patients with PTSD has never been investigated. Using a modified single prolonged stress (mSPS) model in mice, we assessed the anti-PTSD-like effects of early intervention using EA and evaluated changes in lipid composition in the hippocampus and prefrontal cortex (PFC) using a mass spectrometry-based lipidomic approach. mSPS induced changes in lipid composition in the hippocampus, notably in the content of sphingolipids, glycerolipids, and fatty acyls. These lipid changes were more robust than those observed in the PFC. Early intervention with EA after mSPS ameliorated PTSD-like behaviors and partly normalized mSPS-induced lipid changes, notably in the hippocampus. Cumulatively, our data suggest that EA may reverse mSPS-induced PTSD-like behaviors due to region-specific regulation of the brain lipidome, providing new insights into the therapeutic mechanism of EA.
引用
收藏
页数:17
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