The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder

被引:6
作者
Zhou, Cui-Hong [1 ,2 ]
Xue, Fen [1 ,2 ]
Shi, Qing-Qing [1 ]
Xue, Shan-Shan [1 ]
Zhang, Tian [1 ]
Ma, Xin-Xu [1 ]
Yu, Li-Sheng [3 ]
Liu, Chuang [4 ]
Wang, Hua-Ning [1 ,2 ]
Peng, Zheng-Wu [1 ]
机构
[1] Air Force Med Univ, Xijing Hosp, Dept Psychiat, Xian, Peoples R China
[2] Air Force Med Univ, Sch Publ Hlth, Shaanxi Key Lab Free Radical Biol & Med, Dept Toxicol,Minist Educ,Key Lab Hazard Assessmen, Xian, Peoples R China
[3] Shaanxi Prov Peoples Hosp, Dept Gen Med, Xian, Peoples R China
[4] Fourth Mil Med Univ, Xijing Hosp, Dept Obstet, Xian, Peoples R China
来源
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2022年 / 15卷
基金
中国国家自然科学基金;
关键词
electroacupuncture; post-traumatic stress disorder; lipidomics; hippocampus; prefrontal cortex; mouse model; MEMBRANE-LIPIDS; BIPOLAR DISORDER; FATTY-ACIDS; RAT MODEL; ANXIETY; PTSD; DEPRESSION; MEMORY; ACUPUNCTURE; METABOLISM;
D O I
10.3389/fnmol.2022.812479
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The neuroprotective effect of electroacupuncture (EA) treatment has been well studied; growing evidence suggests that changes in lipid composition may be involved in the pathogenesis of post-traumatic stress disorder (PTSD) and may be a target for treatment. However, the influence of early EA intervention on brain lipid composition in patients with PTSD has never been investigated. Using a modified single prolonged stress (mSPS) model in mice, we assessed the anti-PTSD-like effects of early intervention using EA and evaluated changes in lipid composition in the hippocampus and prefrontal cortex (PFC) using a mass spectrometry-based lipidomic approach. mSPS induced changes in lipid composition in the hippocampus, notably in the content of sphingolipids, glycerolipids, and fatty acyls. These lipid changes were more robust than those observed in the PFC. Early intervention with EA after mSPS ameliorated PTSD-like behaviors and partly normalized mSPS-induced lipid changes, notably in the hippocampus. Cumulatively, our data suggest that EA may reverse mSPS-induced PTSD-like behaviors due to region-specific regulation of the brain lipidome, providing new insights into the therapeutic mechanism of EA.
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页数:17
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共 118 条
  • [1] Sex differences and gonadal hormone regulation of brain cardiolipin, a key mitochondrial phospholipid
    Acaz-Fonseca, Estefania
    Ortiz-Rodriguez, Ana
    Miguel Garcia-Segura, Luis
    Astiz, Mariana
    [J]. JOURNAL OF NEUROENDOCRINOLOGY, 2020, 32 (01)
  • [2] Hippocampal dysfunction effects on context memory: Possible etiology for posttraumatic stress disorder
    Acheson, Dean T.
    Gresack, Jodi E.
    Risbrough, Victoria B.
    [J]. NEUROPHARMACOLOGY, 2012, 62 (02) : 674 - 685
  • [3] Synaptic functions of endocannabinoid signaling in health and disease
    Araque, Alfonso
    Castillo, Pablo E.
    Manzoni, Olivier J.
    Tonini, Raffaella
    [J]. NEUROPHARMACOLOGY, 2017, 124 : 13 - 24
  • [4] Volume and shape analysis of the Hippocampus and amygdala in veterans with traumatic brain injury and posttraumatic stress disorder
    Bae, Sujin
    Sheth, Chandni
    Legarreta, Margaret
    McGlade, Erin
    Lyoo, In Kyoon
    Yurgelun-Todd, Deborah A.
    [J]. BRAIN IMAGING AND BEHAVIOR, 2020, 14 (05) : 1850 - 1864
  • [5] Lipid profile and suicide attempt in bipolar disorder: A meta-analysis of published and unpublished data
    Bartoli, Francesco
    Di Brita, Carmen
    Crocamo, Cristina
    Clerici, Massimo
    Carra, Giuseppe
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2017, 79 : 90 - 95
  • [6] Symptom burden and work-related impairment among patients with PTSD and complex PTSD
    Brenner, Lorena
    Koellner, Volker
    Bachem, Rahel
    [J]. EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, 2019, 10 (01)
  • [7] Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder
    Brunkhorst-Kanaan, Nathalie
    Klatt-Schreiner, Katharina
    Hackel, Juliane
    Schroeter, Katrin
    Trautmann, Sandra
    Hahnefeld, Lisa
    Wicker, Sabine
    Reif, Andreas
    Thomas, Dominique
    Geisslinger, Gerd
    Kittel-Schneider, Sarah
    Tegeder, Irmgard
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 95 : 65 - 76
  • [8] Validating Quantitative Untargeted Lipidomics Across Nine Liquid Chromatography-High-Resolution Mass Spectrometry Platforms
    Cajka, Tomas
    Smilowitz, Jennifer T.
    Fiehn, Oliver
    [J]. ANALYTICAL CHEMISTRY, 2017, 89 (22) : 12360 - 12368
  • [9] Membrane Lipids Tune Synaptic Transmission by Direct Modulation of Presynaptic Potassium Channels
    Carta, Mario
    Lanore, Frederic
    Rebola, Nelson
    Szabo, Zsolt
    Da Silva, Silvia Viana
    Lourenco, Joana
    Verraes, Agathe
    Nadler, Andre
    Schultz, Carsten
    Blanchet, Christophe
    Mulle, Christophe
    [J]. NEURON, 2014, 81 (04) : 787 - 799
  • [10] Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression
    Cassol, Edana
    Misra, Vikas
    Morgello, Susan
    Kirk, Gregory D.
    Mehta, Shruti H.
    Gabuzda, Dana
    [J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2015, 69 (01) : 18 - 28