Complications preceding early deaths in Black and White children with acute myeloid leukemia

被引：7

作者：

Winestone, Lena E. ^{[1
,2
,3
,4
]}

Getz, Kelly D. ^{[1
,2
]}

Miller, Tamara P. ^{[1
,2
,4
]}

Li, Yimei ^{[5
]}

Huang, Yuan-Shung ^{[6
]}

Seif, Alix E. ^{[1
,4
]}

Fisher, Brian T. ^{[2
,7
,8
]}

Aplenc, Richard ^{[1
,2
,4
,8
]}

机构：

[1] Childrens Hosp Philadelphia, Div Oncol, 3501 Civ Ctr Blvd,CTRB 10305, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Ctr Pediat Clin Effectiveness, Philadelphia, PA 19104 USA

[3] Univ Penn, Leonard Davis Inst Hlth Econ, Philadelphia, PA 19104 USA

[4] Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[5] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[6] Childrens Hosp Philadelphia, Dept Gen Pediat, Healthcare Analyt Unit, Philadelphia, PA 19104 USA

[7] Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA 19104 USA

[8] Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

PEDIATRIC BLOOD & CANCER | 2017年 / 64卷 / 12期

关键词：

AML; disparities; intensive care; mortality; outcomes research; race; ADMINISTRATIVE DATABASE; INDUCTION THERAPY; ONCOLOGY-GROUP; SURVIVAL; ADOLESCENTS; CHILDHOOD; MORTALITY; ACCURACY;

D O I：

10.1002/pbc.26712

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Black patients have a twofold increased risk of induction mortality compared to White patients with acute myeloid leukemia (AML). We reviewed diagnosis and billing data from Pediatric Health Information System for 28 AML Induction I deaths to investigate conditions preceding death in White and Black patients. Half of deaths occurred within 10 days of initial diagnostic admission. Respiratory, cardiac, renal, and infectious complications were common prior to both White and Black deaths. Deaths in White patients were more commonly preceded by intracranial hemorrhage compared to deaths in Black patients. Future studies should assess management approaches of complications by race to identify modifiable processes that reduce mortality.

引用

页数：4

共 15 条

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