Genetic mutual relationship between PTEN and p53 in gastric cancer

被引：27
作者：
Oki, E [1 ]
Tokunaga, E
Nakamura, T
Ueda, N
Futatsugi, M
Mashino, K
Yamamoto, M
Watanabe, M
Ikebe, M
Kakeji, Y
Baba, H
Maehara, Y
机构：
[1] Kyushu Univ 3 1 1, Grad Sch, Dept Surg & Sci, Higashi Ku, Fukuoka 8128582, Japan
[2] Kyushu Univ, Ctr Integrat Adv Med & Innovat Technol, Higashi Ku, Fukuoka 8128582, Japan
来源：
CANCER LETTERS | 2005年 / 227卷 / 01期
关键词：
PTEN; p53; gastric cancer; loss of heterozygosity;
D O I：
10.1016/j.canlet.2004.12.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：33 / 38
页数：6
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