A note on the antitubercular activities of 1-aryl-5-benzylsulfanyltetrazoles

被引：49

作者：

Adamec, J

Waisser, K

Kunes, J

Kaustová, J

机构：

[1] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Inorgan & Organ Chem, CZ-50005 Hradec Kralove, Czech Republic

[2] Reg Inst Publ Hlth, Dept Diagnost Mycobacteria, Ostrava, Czech Republic

来源：

ARCHIV DER PHARMAZIE | 2005年 / 338卷 / 08期

关键词：

benzylsulranyltetrazoles; Mycobacterium tuberculosis; tuberculostatics; phase-transfer catalysis;

D O I：

10.1002/ardp.200400967

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A set of 32 1-phenyl-5-benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis. The activity against M. tuberculosis becomes higher with increasing electron-accepting properties of the substituents on the phenyl ring. On the other hand, any substitution on the benzylic moiety decreases the activity.

引用

页码：385 / 389

页数：5

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