An evolutionary framework for treating pediatric sarcomas

被引：32

作者：

Reed, Damon R. ^{[1
,2
,3
]}

Metts, Jonathan ^{[4
]}

Pressley, Mariyah ^{[2
,5
]}

Fridley, Brooke L. ^{[2
,6
]}

Hayashi, Masanori ^{[7
]}

Isakoff, Michael S. ^{[8
]}

Loeb, David M. ^{[9
]}

Makanji, Rikesh ^{[10
]}

Roberts, Ryan D. ^{[11
]}

Trucco, Matteo ^{[12
]}

Wagner, Lars M. ^{[13
]}

Alexandrow, Mark G. ^{[2
]}

Gatenby, Robert A. ^{[2
,5
,10
]}

Brown, Joel S. ^{[2
,5
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Interdisciplinary Canc Management, Tampa, FL USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Canc Biol & Evolut Program, Tampa, FL USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Adolescent & Young Adult Program, Tampa, FL USA

[4] Johns Hopkins All Childrens Hosp, Canc & Blood Disorders Inst, St Petersburg, FL USA

[5] H Lee Moffitt Canc Ctr & Res Inst, Integrat Math Oncol, Tampa, FL USA

[6] H Lee Moffitt Canc Ctr & Res Inst, Biostat & Bioinformat Dept, Tampa, FL USA

[7] Univ Colorado Denver, Dept Pediat, Aurora, CO USA

[8] Connecticut Childrens Med Ctr, Ctr Canc & Blood Disorders, Hartford, CT USA

[9] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA

[10] H Lee Moffitt Canc Ctr & Res Inst, Diagnost Imaging & Intervent Radiol, Tampa, FL USA

[11] Nationwide Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Columbus, OH USA

[12] Univ Miami, Dept Pediat, Miami, FL 33152 USA

[13] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA

来源：

CANCER | 2020年 / 126卷 / 11期

基金：

美国国家卫生研究院;

关键词：

adaptive therapy; clinical trial; Ewing sarcoma; evolution; extinction therapy; first strike; osteosarcoma; resistance; rhabdomyosarcoma; second strike; HIGH-GRADE OSTEOSARCOMA; ACUTE MYELOID-LEUKEMIA; GROUPS; 2013; BLUEPRINT; INDUCTION CHEMOTHERAPY; EWINGS-SARCOMA; TUMOR; RHABDOMYOSARCOMA; EURAMOS-1; THERAPY; COMBINATION;

D O I：

10.1002/cncr.32777

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.

引用

页码：2577 / 2587

页数：11

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