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Monash Univ, Alfred Hosp, Dept Epidemiol & Prevent Med, NHMRC Ctr Clin Res Excellence Therapeut, Melbourne, Vic 3004, Australia Monash Univ, Alfred Hosp, Dept Epidemiol & Prevent Med, NHMRC Ctr Clin Res Excellence Therapeut, Melbourne, Vic 3004, Australia