Reliable detection of clonal IgH/Bcl2 MBR rearrangement in follicular lymphoma: methodology and clinical significance

被引：14

作者：

Iqbal, S

Jenner, MJR

Summers, KE

Davies, AJ

Matthews, J

Norton, AJ

Calaminici, M

Rohatiner, AZ

Fitzgibbon, J

Lister, TA

Goff, LK

机构：

[1] St Bartholomews Hosp, Ctr Res UK Med Oncol Unit, London, England

[2] St Bartholomews Hosp, Dept Haematol, London, England

[3] St Bartholomews Hosp, Dept Med Oncol, London, England

[4] St Bartholomews Hosp, Dept Histopathol, London, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 124卷 / 03期

关键词：

follicular lymphoma; major breakpoint region; RQ-PCR;

D O I：

10.1046/j.1365-2141.2003.04796.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prognostic significance of IgH/Bcl2 rearrangement in follicular lymphoma (FL) remains contentious; polymerase chain reaction (PCR) methodology and tissue source variability may account for some inconsistencies. As IgH/Bcl2 major breakpoint region (MBR) sequences may be found in normal blood, an MBR+ result by conventional PCR in blood/bone marrow may not indicate FL. To establish tumour MBR status, 190 lymphoid tissue samples with histologically evident FL (and therefore >1% tumour cells) were examined by real-time quantifiable PCR; 50% (95/190) had clonal MBR IgH/Bcl2 (MBR was considered clonal when >1%). Overall survival (median = 11.5 years) of MBR+ and MBR- patients was not significantly different.

引用

页码：325 / 328

页数：4

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