Responsive functionalized MoSe2 nanosystem for highly efficient synergistic therapy of breast cancer

被引:37
作者
Liu, Yanan [1 ,2 ,3 ]
Wei, Chunfang [1 ,2 ,3 ]
Lin, Ange [3 ]
Pan, Jiali [3 ]
Chen, Xu [3 ]
Zhu, Xufeng [3 ]
Gong, Youcong [3 ]
Yuan, Guanglong [3 ]
Chen, Lanmei [1 ]
Liu, Jie [1 ,2 ,3 ]
Luo, Zhaohui [2 ]
机构
[1] Guangdong Med Univ, Sch Pharm, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China
[2] Guilin Med Univ, Coll Pharm, Guangxi 541004, Guilin, Peoples R China
[3] Jinan Univ, Coll Chem & Mat Sci, Dept Chem, Guangzhou 510632, Peoples R China
基金
中国国家自然科学基金;
关键词
Photothermal therapy; Photodynamic therapy; Multimodal imaging; Photostability; Molybdenum selenide; Breast cancer; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; IN-VIVO; THERANOSTIC AGENT; QUANTUM DOTS; ONE-POT; NANOSHEETS; PHOTOSENSITIZER; GRAPHENE; CORE;
D O I
10.1016/j.colsurfb.2020.110820
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The photothermal/photodynamic synergistic therapy is a promising tumor treatment, but developing nanosystems that achieve synchronous photothermal/photodynamic functions is still quite challenging. Here, we use a simple method to synthesize molybdenum selenide nanoparticles (MoSe2 NPs) with a photothermal effect as a carrier, and load a photosensitizer ICG to form a nanosystem (MoSe2@ICG-PDA-HA)with dual photothermal/photodynamic functions under near-infrared irradiation. In addition, the surface modification of the nanosystem with acid-responsive release polydopamine (PDA) and tumor-targeted hyaluronic acid (HA) enhanced the stability of the photosensitizer ICG and the accumulation of ICG at tumor sites. The multicellular sphere assay simulated solid tumors and demonstrated that MoSe2@ICG-PDA-HA could significantly inhibit the 4T1 cell growth. The anti-tumor experiments in tumor-bearing mice showed that MoSe2@ICG-PDA-HA not only significantly inhibited the growth of 4T1 subcutaneous tumors, but also inhibited their metastasis. This study presented a nanosystem that could improve the photostability of optical materials and enhance the photothermal/photodynamic synergy effect, providing a new idea for finding a way to effectively treat breast cancer.
引用
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页数:13
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