Responsive functionalized MoSe2 nanosystem for highly efficient synergistic therapy of breast cancer

被引：37

作者：

Liu, Yanan ^{[1
,2
,3
]}

Wei, Chunfang ^{[1
,2
,3
]}

Lin, Ange ^{[3
]}

Pan, Jiali ^{[3
]}

Chen, Xu ^{[3
]}

Zhu, Xufeng ^{[3
]}

Gong, Youcong ^{[3
]}

Yuan, Guanglong ^{[3
]}

Chen, Lanmei ^{[1
]}

Liu, Jie ^{[1
,2
,3
]}

Luo, Zhaohui ^{[2
]}

机构：

[1] Guangdong Med Univ, Sch Pharm, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China

[2] Guilin Med Univ, Coll Pharm, Guangxi 541004, Guilin, Peoples R China

[3] Jinan Univ, Coll Chem & Mat Sci, Dept Chem, Guangzhou 510632, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2020年 / 189卷

基金：

中国国家自然科学基金;

关键词：

Photothermal therapy; Photodynamic therapy; Multimodal imaging; Photostability; Molybdenum selenide; Breast cancer; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; IN-VIVO; THERANOSTIC AGENT; QUANTUM DOTS; ONE-POT; NANOSHEETS; PHOTOSENSITIZER; GRAPHENE; CORE;

D O I：

10.1016/j.colsurfb.2020.110820

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The photothermal/photodynamic synergistic therapy is a promising tumor treatment, but developing nanosystems that achieve synchronous photothermal/photodynamic functions is still quite challenging. Here, we use a simple method to synthesize molybdenum selenide nanoparticles (MoSe2 NPs) with a photothermal effect as a carrier, and load a photosensitizer ICG to form a nanosystem (MoSe2@ICG-PDA-HA)with dual photothermal/photodynamic functions under near-infrared irradiation. In addition, the surface modification of the nanosystem with acid-responsive release polydopamine (PDA) and tumor-targeted hyaluronic acid (HA) enhanced the stability of the photosensitizer ICG and the accumulation of ICG at tumor sites. The multicellular sphere assay simulated solid tumors and demonstrated that MoSe2@ICG-PDA-HA could significantly inhibit the 4T1 cell growth. The anti-tumor experiments in tumor-bearing mice showed that MoSe2@ICG-PDA-HA not only significantly inhibited the growth of 4T1 subcutaneous tumors, but also inhibited their metastasis. This study presented a nanosystem that could improve the photostability of optical materials and enhance the photothermal/photodynamic synergy effect, providing a new idea for finding a way to effectively treat breast cancer.

引用

页数：13

共 50 条

[1] Self-Assembled Peptide- and Protein-Based Nanomaterials for Antitumor Photodynamic and Photothermal Therapy [J].

Abbas, Manzar ;

Zou, Qianli ;

Li, Shukun ;

Yan, Xuehai .

ADVANCED MATERIALS, 2017, 29 (12)

[2] Recent advances in the field of transition metal dichalcogenides for biomedical applications [J].

Agarwal, Vipul ;

Chatterjee, Kaushik .

NANOSCALE, 2018, 10 (35) :16365-16397

[3] Near-Infrared-Absorbing Gold Nanopopcorns with Iron Oxide Cluster Core for Magnetically Amplified Photothermal and Photodynamic Cancer Therapy [J].

Bhana, Saheel ;

Lin, Gan ;

Wang, Lijia ;

Starring, Hunter ;

Mishra, Sanjay R. ;

Liu, Gang ;

Huang, Xiaohua .

ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (21) :11637-11647

[4] Reduced Graphene Oxide/Amaranth Extract/AuNPs Composite Hydrogel on Tumor Cells as Integrated Platform for Localized and Multiple Synergistic Therapy [J].

Chang, Guanru ;

Wang, Yunlong ;

Gong, Baoyou ;

Xiao, Yazhong ;

Chen, Yan ;

Wang, Shaohua ;

Li, Shikuo ;

Huang, Fangzhi ;

Shen, Yuhua ;

Xie, Anjian .

ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (21) :11246-11256

[5] Near-IR-triggered photothermal/photodynamic dual-modality therapy system via chitosan hybrid nanospheres [J].

Chen, Rui ;

Wang, Xin ;

Yao, Xikuan ;

Zheng, Xianchuang ;

Wang, Jing ;

Jiang, Xiqun .

BIOMATERIALS, 2013, 34 (33) :8314-8322

[6] PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual-Modal CT/Photoacoustic Imaging Guided Photothermal Therapy [J].

Cheng, Liang ;

Liu, Jingjing ;

Gu, Xing ;

Gong, Hua ;

Shi, Xiaoze ;

Liu, Teng ;

Wang, Chao ;

Wang, Xiaoyong ;

Liu, Gang ;

Xing, Huaiyong ;

Bu, Wenbo ;

Sun, Baoquan ;

Liu, Zhuang .

ADVANCED MATERIALS, 2014, 26 (12) :1886-1893

[7]

Chhowalla M, 2013, NAT CHEM, V5, P263, DOI [10.1038/NCHEM.1589, 10.1038/nchem.1589]

[8] Nanotechnology for Multimodal Synergistic Cancer Therapy [J].

Fan, Wenpei ;

Yung, Bryant ;

Huang, Peng ;

Chen, Xiaoyuan .

CHEMICAL REVIEWS, 2017, 117 (22) :13566-13638

[9] Magnetic and fluorescent graphene for dual modal imaging and single light induced photothermal and photodynamic therapy of cancer cells [J].

Gollavelli, Ganesh ;

Ling, Yong-Chien .

BIOMATERIALS, 2014, 35 (15) :4499-4507

[10] Engineering of Multifunctional Nano-Micelles for Combined Photothermal and Photodynamic Therapy Under the Guidance of Multimodal Imaging [J].

Gong, Hua ;

Dong, Ziliang ;

Liu, Yumeng ;

Yin, Shengnan ;

Cheng, Liang ;

Xi, Wenyao ;

Xiang, Jian ;

Liu, Kai ;

Li, Yonggang ;

Liu, Zhuang .

ADVANCED FUNCTIONAL MATERIALS, 2014, 24 (41) :6492-6502

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