Synthesis of Degradable Poly[(Ethylene Glycol)-co-(Glycolic Acid)] via the Post-Polymerization Oxyfunctionalization of Poly(Ethylene Glycol)

被引：17

作者：

Liu, Di ^{[1
]}

Bielawski, Christopher W. ^{[2
,3
,4
]}

机构：

[1] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA

[2] Inst Basic Sci, CMCM, Ulsan 44919, South Korea

[3] Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea

[4] Ulsan Natl Inst Sci & Technol, Dept Energy Engn, Ulsan 44919, South Korea

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2016年 / 37卷 / 19期

基金：

美国国家科学基金会; 新加坡国家研究基金会;

关键词：

biodegradable polymers; drug delivery systems; poly(ethylene glycol); post-polymerization modification; ruthenium; DRUG-DELIVERY; RUTHENIUM TETROXIDE; PEGYLATION; OXIDATION; PEG; THERAPEUTICS;

D O I：

10.1002/marc.201600336

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

To enhance the limited degradability of poly(ethylene glycol) (PEG), a straightforward method of synthesizing poly[(ethylene glycol)-co-(glycolic acid)] (P(EG-co-GA)) via a ruthenium- catalyzed, post-polymerization oxyfunctionalization of various PEGs is developed. Using this method, a set of copolymers with GA compositions of up to 8 mol% are prepared with minimal reduction in molecular weight (<10%) when compared to their commercially available starting materials. The P(EG-co-GA) copolymers are shown to undergo hydrolysis under mild conditions.

引用

页码：1587 / 1592

页数：6

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