Recent advances of microRNA-based molecular diagnostics to reduce false-positive lung cancer imaging

被引：31

作者：

Boeri, Mattia ^{[1
]}

Sestini, Stefano ^{[2
]}

Fortunato, Orazio ^{[1
]}

Verri, Carla ^{[1
]}

Suatoni, Paola ^{[2
]}

Pastorino, Ugo ^{[2
]}

Sozzi, Gabriella ^{[1
]}

机构：

[1] Fdn IRCCS Ist Nazl Tumori, Dept Expt Oncol & Mol Med, Tumor Genom Unit, I-20133 Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Dept Surg, Thorac Surg Unit, I-20133 Milan, Italy

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2015年 / 15卷 / 06期

关键词：

biomarkers; circulating microRNA; LDCT; lung cancer; screening; DOSE SPIRAL CT; COMPUTED-TOMOGRAPHY; CIRCULATING MICRORNAS; MESENCHYMAL TRANSITION; TRAIL RESISTANCE; HEAVY SMOKERS; EXPRESSION; PLASMA; SERUM; METASTASIS;

D O I：

10.1586/14737159.2015.1041377

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Lung cancer is the leading cause of cancer deaths in the world. Advances in early detection crucial to enable timely curative surgery have been made in recent years. Cost-benefit profiles of lung cancer screening in smokers by low-dose computed tomography are still under evaluation. In particular, the high false-positive rates of low-dose computed tomography, together with the issue of overdiagnosis and the overall costs of screening, prompted a focus on the development of noninvasive complementary biomarkers to implement lung cancer screening. MicroRNA are a new class of blood-based biomarkers useful for early lung cancer detection and prognosis definition. Here, we discuss the seminal publications that reported circulating microRNA signatures with the greatest potential to impact clinical activity and patient care.

引用

页码：801 / 813

页数：13

共 122 条

[1] Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening [J].

Aberle, Denise R. ;

Adams, Amanda M. ;

Berg, Christine D. ;

Black, William C. ;

Clapp, Jonathan D. ;

Fagerstrom, Richard M. ;

Gareen, Ilana F. ;

Gatsonis, Constantine ;

Marcus, Pamela M. ;

Sicks, JoRean D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (05) :395-409

[2] Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].

Arroyo, Jason D. ;

Chevillet, John R. ;

Kroh, Evan M. ;

Ruf, Ingrid K. ;

Pritchard, Colin C. ;

Gibson, Donald F. ;

Mitchell, Patrick S. ;

Bennett, Christopher F. ;

Pogosova-Agadjanyan, Era L. ;

Stirewalt, Derek L. ;

Tait, Jonathan F. ;

Tewari, Muneesh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008

[3] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[4] Computed tomography screening and lung cancer outcomes [J].

Bach, Peter B. ;

Jett, James R. ;

Pastorino, Ugo ;

Tockman, Melvyn S. ;

Swensen, Stephen J. ;

Begg, Colin B. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (09) :953-961

[5] Benefits and Harms of CT Screening for Lung Cancer A Systematic Review [J].

Bach, Peter B. ;

Mirkin, Joshua N. ;

Oliver, Thomas K. ;

Azzoli, Christopher G. ;

Berry, Donald A. ;

Brawley, Otis W. ;

Byers, Tim ;

Colditz, Graham A. ;

Gould, Michael K. ;

Jett, James R. ;

Sabichi, Anita L. ;

Smith-Bindman, Rebecca ;

Wood, Douglas E. ;

Qaseem, Amir ;

Detterbeck, Frank C. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (22) :2418-2429

[6] miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner [J].

Bandi, Nora ;

Vassella, Erik .

MOLECULAR CANCER, 2011, 10

[7] miR-15a and miR-16 Are Implicated in Cell Cycle Regulation in a Rb-Dependent Manner and Are Frequently Deleted or Down-regulated in Non-Small Cell Lung Cancer [J].

Bandi, Nora ;

Zbinden, Samuel ;

Gugger, Mathias ;

Arnold, Marlene ;

Kocher, Verena ;

Hasan, Lara ;

Kappeler, Andreas ;

Brunner, Thomas ;

Vassella, Erik .

CANCER RESEARCH, 2009, 69 (13) :5553-5559

[8] Randomized study on early detection of lung cancer with MSCT in Germany: study design and results of the first screening round [J].

Becker, N. ;

Motsch, E. ;

Gross, M. -L. ;

Eigentopf, A. ;

Heussel, C. P. ;

Dienemann, H. ;

Schnabel, P. A. ;

Pilz, L. ;

Eichinger, M. ;

Optazaite, D. -E. ;

Puderbach, M. ;

Tremper, J. ;

Delorme, S. .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2012, 138 (09) :1475-1486

[9] Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available [J].

Benes, Vladimir ;

Castoldi, Mirco .

METHODS, 2010, 50 (04) :244-249

[10] Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma [J].

Bhatti, Imran ;

Lee, Andrew ;

James, Victoria ;

Hall, Richard I. ;

Lund, Jonathan N. ;

Tufarelli, Cristina ;

Lobo, Dileep N. ;

Larvin, Michael .

JOURNAL OF GASTROINTESTINAL SURGERY, 2011, 15 (01) :199-208

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