Characterization of hepatitis C virus in chronic hepatitis patients: genotypes in the State of Amazonas, Brazil

被引：5

作者：

Araujo, Ana Ruth ^{[4
]}

de Almeida, Carlos Maurico

Fraporti, Liziara ^{[1
,4
]}

Garcia, Nadja ^{[1
,4
]}

de Lima, Tatiane Amabili ^{[1
]}

Viana Maia, Laura Patricia ^{[1
,4
]}

Torres, Katia Luz ^{[1
]}

Tarrago, Andrea Monteiro ^{[1
]}

Victoria, Flamir

Victoria, Marilu

Tateno, Adriana ^{[2
]}

Levi, Jose Eduardo ^{[2
]}

Talhari, Sinesio

Malheiro, Adriana ^{[3
,4
]}

机构：

[1] Fundacao Hematol & Hemoterapia Amazonas, Lab Imunol, Diretoria Ensino & Pesquisa, Manaus, Amazonas, Brazil

[2] Inst Med Trop Sao Paulo, Virol Lab, Sao Paulo, Brazil

[3] Fundacao Med Trop Amazonas, Ambulatorio Virol, HEMOAM, BR-69050002 Manaus, Amazonas, Brazil

[4] Univ Fed Amazonas, Dept Parasitol, Inst Ciencias Biol, Manaus, Amazonas, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2011年 / 44卷 / 05期

关键词：

Hepatitis C virus; Genotyping; Hepatitis;

D O I：

10.1590/S0037-86822011000500024

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Introduction: In the State of Amazonas, data regarding the prevalence of different genotypes of hepatitis C virus remains scarce. Methods: The genotype of 69 HCV positive patients was determined. An in-house standardized nested-PCR was used to detect HCV RNA. Genotype assignment was based on type-specific motifs on the sequenced amplicons delimited by primers HC11/HC18 from the 5' untranslated region. Results: Of the 69 patients studied, 65.2% were male and 34.8% were female. Genotype 1 showed the greatest prevalence, followed by 3 and 2. Conclusions: These data suggesting that Manaus is the point of arrival of HCV in the State of Amazonas.

引用

页码：638 / 640

页数：3

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