Effects of Microglia on Neurogenesis

被引：152

作者：

Sato, Kaoru ^{[1
]}

机构：

[1] Natl Inst Hlth Sci, Div Pharmacol, Neuropharmacol Lab, Setagaya Ku, Tokyo 1588501, Japan

来源：

GLIA | 2015年 / 63卷 / 08期

关键词：

microglia; subventricular zone; subgranular zone; neurogenesis; cytokine; CENTRAL-NERVOUS-SYSTEM; NEURAL PRECURSOR CELLS; ADULT HIPPOCAMPAL NEUROGENESIS; SUBVENTRICULAR ZONE; STEM-CELLS; PROGENITOR CELLS; DENTATE GYRUS; DIFFERENTIAL EXPRESSION; INCREASES NEUROGENESIS; INFLAMMATORY RESPONSE;

D O I：

10.1002/glia.22858

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the organism. A comparison of microglial roles in neurogenesis in these two regions indicates that microglia regulate neurogenesis in a temporally and spatially specific manner. Microglia may also sense signals from the surrounding environment and have regulatory effects on neurogenesis. We speculate microglia function as a hub for the information obtained from the inner and outer brain regions for regulating neurogenesis. GLIA 2015;63:1394-1405

引用

页码：1394 / 1405

页数：12

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