Type 3 Diabetes and Its Role Implications in Alzheimer's Disease

被引：234

作者：

Thuy Trang Nguyen ^{[1
]}

Qui Thanh Hoai Ta ^{[2
]}

Thi Kim Oanh Nguyen ^{[3
]}

Thi Thuy Dung Nguyen ^{[4
]}

Vo Van Giau ^{[5
,6
]}

机构：

[1] Ho Chi Minh City Univ Technol HUTECH, Fac Pharm, Ho Chi Minh City 700000, Vietnam

[2] Duy Tan Univ, Inst Res & Dev, Danang 550000, Vietnam

[3] Ho Chi Minh City Univ Food Ind, Fac Food Sci & Technol, Ho Chi Minh City 700000, Vietnam

[4] Nguyen Tat Thanh Univ, Fac Environm & Food Engn, Ho Chi Minh City 700000, Vietnam

[5] Gachon Univ, Dept Ind & Environm Engn, Grad Sch Environm, 1342 Sungnam Daero, Seongnam Si 461701, Gyeonggi Do, South Korea

[6] Gachon Univ, Gachon Med Res Inst, Dept Bionano Technol, 1342 Sungnam Daero, Seongnam Si 461701, Gyeonggi Do, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Alzheimer's disease; hypometabolism; type; 2; diabetes; 3; insulin resistance; AMYLOID PRECURSOR PROTEIN; BRAIN INSULIN-RESISTANCE; CEREBRAL GLUCOSE-METABOLISM; INTRANASAL INSULIN; MEMORY IMPAIRMENT; MOUSE MODEL; RECEPTOR SUBSTRATE; DEGRADING ENZYME; APOLIPOPROTEIN-E; NEURONAL DAMAGE;

D O I：

10.3390/ijms21093165

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in debate. However, poorly controlled blood sugar may increase the risk of developing Alzheimer's. This relationship is so strong that some have called Alzheimer's "diabetes of the brain" or "type 3 diabetes (T3D)". Given more recent studies continue to indicate evidence linking T3D with AD, this review aims to demonstrate the relationship between T3D and AD based on the fact that both the processing of amyloid-beta (A beta) precursor protein toxicity and the clearance of A beta are attributed to impaired insulin signaling, and that insulin resistance mediates the dysregulation of bioenergetics and progress to AD. Furthermore, insulin-related therapeutic strategies are suggested to succeed in the development of therapies for AD by slowing down their progressive nature or even halting their future complications.

引用

页数：16

共 105 条

[21] Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation [J].

Correia, Sonia C. ;

Santos, Renato X. ;

Carvalho, Cristina ;

Cardoso, Susana ;

Candeias, Emanuel ;

Santos, Maria S. ;

Oliveira, Catarina R. ;

Moreira, Paula I. .

BRAIN RESEARCH, 2012, 1441 :64-78

[22] Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype [J].

Craft, S ;

Asthana, S ;

Cook, DG ;

Baker, LD ;

Cherrier, M ;

Purganan, K ;

Wait, C ;

Petrova, A ;

Latendresse, S ;

Watson, GS ;

Newcomer, JW ;

Schellenberg, GD ;

Krohn, AJ .

PSYCHONEUROENDOCRINOLOGY, 2003, 28 (06) :809-822

[23] Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers [J].

De Felice, Fernanda G. ;

Vieira, Marcelo N. N. ;

Bomfim, Theresa R. ;

Decker, Helena ;

Velasco, Pauline T. ;

Lambert, Mary P. ;

Viola, Kirsten L. ;

Zhao, Wei-Qin ;

Ferreira, Sergio T. ;

Klein, William L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (06) :1971-1976

[24] Type 3 diabetes is sporadic Alzheimer's disease: Mini-review [J].

de la Monte, Suzanne M. .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2014, 24 (12) :1954-1960

[25]

de la Monte SM, 2012, CURR ALZHEIMER RES, V9, P35

[26] Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential [J].

de Matos, Ana Marta ;

de Macedo, Maria Paula ;

Rauter, Amelia Pilar .

MEDICINAL RESEARCH REVIEWS, 2018, 38 (01) :261-324

[27] Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-epsilon 4-associated Alzheimer's disease [J].

Delikkaya, Buesra ;

Moriel, Natalia ;

Tong, Ming ;

Gallucci, Gina ;

de la Monte, Suzanne M. .

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, 2019, 11 (01) :392-404

[28] INSULINLIKE AND GLUCAGONLIKE PEPTIDES IN THE BRAIN [J].

DORN, A ;

BERNSTEIN, HG ;

RINNE, A ;

ZIEGLER, M ;

HAHN, HJ ;

ANSORGE, S .

ANATOMICAL RECORD, 1983, 207 (01) :69-77

[29] Metabolic Alterations Associated to Brain Dysfunction in Diabetes [J].

Duarte, Joao M. N. .

AGING AND DISEASE, 2015, 6 (05) :304-321

[30] Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology [J].

Escribano, Luis ;

Simon, Ana-Maria ;

Gimeno, Esther ;

Cuadrado-Tejedor, Mar ;

Lopez de Maturana, Rakel ;

Garcia-Osta, Ana ;

Ricobaraza, Ana ;

Perez-Mediavilla, Alberto ;

Del Rio, Joaquin ;

Frechilla, Diana .

NEUROPSYCHOPHARMACOLOGY, 2010, 35 (07) :1593-1604

← 1 2 3 4 5 6 7 8 9 10 →