Quinolone Induction of qnrVS1 in Vibrio splendidus and Plasmid-Carried qnrS1 in Escherichia coli, a Mechanism Independent of the SOS System

被引：18

作者：

Okumura, Ryo ^{[1
,2
,3
]}

Liao, Chun-Hsing ^{[1
,2
,4
]}

Gavin, Mariah ^{[1
,2
]}

Jacoby, George A. ^{[5
]}

Hooper, David C. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Daiichi Sankyo Co Ltd, Biol Res Labs, Tokyo, Japan

[4] Far Eastern Mem Hosp, Taipei, Taiwan

[5] Lahey Clin Fdn, Burlington, MA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 12期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; RESISTANCE; TRANSCRIPTION; EXPOSURE;

D O I：

10.1128/AAC.05142-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Plasmid-carried qnrS1 is derived from Vibrio splendidus chromosomal qnrVS1. qnrVS1 transcripts increased 21- to 34-fold with subinhibitory concentrations of ciprofloxacin but much less with mitomycin. No LexA binding sites were upstream of qnrS1 or qnrVS1, and similar induction levels were observed in lexA-positive and lexA-negative Escherichia coli strains with native qnrS1 plasmid pMG306 but not with pUC18-cloned qnrS1 or qnrVS1. Thus, qnrS1 induction by quinolones is independent of the SOS system and requires sequence besides that of the structural gene.

引用

页码：5942 / 5945

页数：4

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