Facile radical trifluoromethylation of lithium enolates

被引：90

作者：

Itoh, Y ^{[1
]}

Mikami, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Tokyo 1528552, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol0517574

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Highly basic lithium enolates are shown to be applicable to radical trifluoromethylation. The reaction is extremely fast, and the minimum reaction time is similar to 1 s.

引用

页码：4883 / 4885

页数：3

共 28 条

[1]

*AM CHEM SOC, 2000, ASYMMETRIC FLUORORGA

[2]

Banks R.E., 1994, ORGANOFLUORINE CHEM

[3] CONDENSATION OF PERFLUOROALKYL IODIDES WITH UNSATURATED NITROGEN-COMPOUNDS [J].

CANTACUZENE, D ;

WAKSELMAN, C ;

DORME, R .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1977, (12) :1365-1371

[4]

Chambers R. D., 1997, ORGANOFLUORINE CHEM

[5]

Hiyama T., 2013, ORGANOFLUORINE COMPO

[6]

HUDLICKY M, 1967, CHEM ORGANIC FLUORIN

[7] ELECTRONEGATIVITY OF GROUPS [J].

HUHEEY, JE .

JOURNAL OF PHYSICAL CHEMISTRY, 1965, 69 (10) :3284-&

[8] DIASTEREOSELECTIVE TRIFLUOROMETHYLATION OF CHIRAL IMIDE ENOLATES WITH IODOTRIFLUOROMETHANE MEDIATED BY TRIETHYLBORANE [J].

ISEKI, K ;

NAGAI, T ;

KOBAYASHI, Y .

TETRAHEDRON LETTERS, 1993, 34 (13) :2169-2170

[9] DIASTEREOSELECTIVE TRIFLUOROMETHYLATION OF CHIRAL IMIDE ENOLATES WITH IODOTRIFLUOROMETHANE MEDIATED BY TRIETHYLBORANE [J].

ISEKI, K ;

NAGAI, T ;

KOBAYASHI, Y .

TETRAHEDRON-ASYMMETRY, 1994, 5 (06) :961-974

[10] Catalytic asymmetric synthesis of chiral fluoroorganic compounds [J].

Iseki, K .

TETRAHEDRON, 1998, 54 (46) :13887-13914

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