Postural Control in Children with Cerebellar Ataxia

被引:15
作者
Farinelli, Veronica [1 ]
Palmisano, Chiara [2 ,3 ]
Marchese, Silvia Maria [1 ]
Strano, Camilla Mirella Maria [1 ]
D'Arrigo, Stefano [4 ]
Pantaleoni, Chiara [4 ]
Ardissone, Anna [5 ]
Nardocci, Nardo [5 ]
Esposti, Roberto [1 ]
Cavallari, Paolo [1 ]
机构
[1] Univ Milan, Human Physiol Sect, Dept Pathophysiol & Transplantat, I-20133 Milan, Italy
[2] Politecn Milan, Movement Biomech & Motor Control Lab, Dept Elect Informat & Bioengn, I-20133 Milan, Italy
[3] Julius Maximilian Univ Wurzburg, Dept Neurol, Univ Hosp, D-97080 Wurzburg, Germany
[4] Fdn IRCCS Ist Neurol C Besta, Dev Neurol Dept, I-20133 Besta, Italy
[5] Fdn IRCCS Ist Neurol C Besta, UOC Neuropsichiatria Infantile, I-20133 Besta, Italy
来源
APPLIED SCIENCES-BASEL | 2020年 / 10卷 / 05期
关键词
children; gait initiation; postural control; generalized cerebellar atrophy; cerebellar vermis hypoplasia; progressive ataxia; compensatory strategies; PERTURBED STEP INITIATION; GAIT INITIATION; BASAL GANGLIA; ADJUSTMENTS; STIMULATION; MOVEMENTS; RESPONSES; PATTERNS; BALANCE; CORTEX;
D O I
10.3390/app10051606
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Controlling posture, i.e., governing the ensemble of involuntary muscular activities that manage body equilibrium, represents a demanding function in which the cerebellum plays a key role. Postural activities are particularly important during gait initiation when passing from quiet standing to locomotion. Indeed, several studies used such motor task for evaluating pathological conditions, including cerebellar disorders. The linkage between cerebellum maturation and the development of postural control has received less attention. Therefore, we evaluated postural control during quiet standing and gait initiation in children affected by a slow progressive generalized cerebellar atrophy (SlowP) or non-progressive vermian hypoplasia (Joubert syndrome, NonP), compared to that of healthy children (H). Despite the similar clinical evaluation of motor impairments in NonP and SlowP, only SlowP showed a less stable quiet standing and a shorter and slower first step than H. Moreover, a descriptive analysis of lower limb and back muscle activities suggested a more severe timing disruption in SlowP. Such differences might stem from the extent of cerebellar damage. However, literature reports that during childhood, neural plasticity of intact brain areas could compensate for cerebellar agenesis. We thus proposed that the difference might stem from disease progression, which contrasts the consolidation of compensatory strategies.
引用
收藏
页数:13
相关论文
共 57 条
  • [21] Asymmetry of Anticipatory Postural Adjustment During Gait Initiation
    Hiraoka, Koichi
    Hatanaka, Ryota
    Nikaido, Yasutaka
    Jono, Yasutomo
    Nomura, Yoshifumi
    Tani, Keisuke
    Chujo, Yuta
    [J]. JOURNAL OF HUMAN KINETICS, 2014, 42 (01) : 7 - 14
  • [22] Hof A.L., 1996, GAIT POSTURE, V4, P222
  • [23] The cerebellum communicates with the basal ganglia
    Hoshi, E
    Tremblay, L
    Féger, J
    Carras, PL
    Strick, PL
    [J]. NATURE NEUROSCIENCE, 2005, 8 (11) : 1491 - 1493
  • [24] Specific influences of cerebellar dysfunctions on gait
    Ilg, Winfried
    Golla, Heidrun
    Thier, Peter
    Giese, Martin A.
    [J]. BRAIN, 2007, 130 : 786 - 798
  • [25] Gait Initiation in Children with Rett Syndrome
    Isaias, Ioannis Ugo
    Dipaola, Mariangela
    Michi, Marlies
    Marzegan, Alberto
    Volkmann, Jens
    Roidi, Marina L. Rodocanachi
    Frigo, Carlo Albino
    Cavallari, Paolo
    [J]. PLOS ONE, 2014, 9 (04):
  • [26] Anticipatory control related to the upward propulsive force during the rising on tiptoe from an upright standing position
    Ito, T
    Azuma, T
    Yamashita, N
    [J]. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2004, 92 (1-2) : 186 - 195
  • [27] Ivry R B, 1989, J Cogn Neurosci, V1, P136, DOI 10.1162/jocn.1989.1.2.136
  • [28] The cerebellum and event timing
    Ivry, RB
    Spencer, RM
    Zelaznik, HN
    Diedrichsen, J
    [J]. CREBELLUM: RECENT DEVELOPMENTS IN CEREBELLAR RESEARCH, 2002, 978 : 302 - 317
  • [29] The build-up of anticipatory behaviour - An analysis of the development of gait initiation in children
    Ledebt, A
    Bril, B
    Breniere, Y
    [J]. EXPERIMENTAL BRAIN RESEARCH, 1998, 120 (01) : 9 - 17
  • [30] Anticipatory postural adjustment patterns during gait initiation across the adult lifespan
    Lu, Chiahao
    Huffmaster, Sommer L. Amundsen
    Harvey, Jack C.
    MacKinnon, Colum D.
    [J]. GAIT & POSTURE, 2017, 57 : 182 - 187