Vitamin B3 and sirtuin function

被引：72

作者：

Denu, JM ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Med, Dept Biomol Chem, Madison, WI 53706 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 09期

关键词：

D O I：

10.1016/j.tibs.2005.07.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sirtuins are NAD(+)-dependent protein deacetylases that are involved in transcriptional regulation, metabolism, apoptosis, differentiation and ageing. These unique enzymes are inhibited by nicotinamide, which is a form of vitamin B-3. Recent studies have uncovered the molecular basis for nicotinamide inhibition, and provided the framework to understand the physiological processes mediated by sirtuins and to develop strategies to modulate their cellular activity.

引用

页码：479 / 483

页数：5

共 28 条

[1] Mechanism of sirtuin inhibition by nicotinamide:: Altering the NAD+ cosubstrate specificity of a Sir2 enzyme [J].

Avalos, JL ;

Bever, KM ;

Wolberger, C .

MOLECULAR CELL, 2005, 17 (06) :855-868

[2] Structural basis for the mechanism and regulation of Sir2 enzymes [J].

Avalos, JL ;

Boeke, JD ;

Wolberger, C .

MOLECULAR CELL, 2004, 13 (05) :639-648

[3] Back in fashion [J].

Bell, E .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (03) :148-148

[4] The new life of a centenarian:: signalling functions of NAD(P) [J].

Berger, F ;

Ramírez-Hernández, MH ;

Ziegler, M .

TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (03) :111-118

[5] Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1 [J].

Bitterman, KJ ;

Anderson, RM ;

Cohen, HY ;

Latorre-Esteves, M ;

Sinclair, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) :45099-45107

[6] The Sir2 family of protein deacetylases [J].

Blander, G ;

Guarente, L .

ANNUAL REVIEW OF BIOCHEMISTRY, 2004, 73 :417-435

[7] Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases [J].

Borra, MT ;

O'Neill, FJ ;

Jackson, MD ;

Marshall, B ;

Verdin, E ;

Foltz, KR ;

Denu, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (15) :12632-12641

[8] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

[9] Structural basis for the NAD-dependent deacetylase mechanism of Sir2 [J].

Chang, JH ;

Kim, HC ;

Hwang, KY ;

Lee, JW ;

Jackson, SP ;

Bell, SD ;

Cho, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (37) :34489-34498

[10] Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity [J].

Daitoku, H ;

Hatta, M ;

Matsuzaki, H ;

Aratani, S ;

Ohshima, T ;

Miyagishi, M ;

Nakajima, T ;

Fukamizu, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (27) :10042-10047

← 1 2 3 →