Abnormal cortical responses elicited by audiovisual movies in patients with autism spectrum disorder with atypical sensory behavior: A magnetoencephalographic study

被引：6

作者：

Matsuzaki, Junko ^{[1
,2
]}

Kagitani-Shimono, Kuriko ^{[1
,2
,3
]}

Aoki, Sho ^{[1
]}

Hanaie, Ryuzo ^{[2
]}

Kato, Yoko ^{[1
]}

Nakanishi, Mariko ^{[2
]}

Tatsumi, Aika ^{[2
]}

Tominaga, Koji ^{[1
,3
]}

Yamamoto, Tomoka ^{[2
]}

Nagai, Yukie ^{[4
]}

Mohri, Ikuko ^{[1
,2
,3
]}

Taniike, Masako ^{[1
,2
,3
]}

机构：

[1] Osaka Univ, United Grad Sch Child Dev, Dept Child Dev, Div Dev Neurosci, Osaka, Japan

[2] Osaka Univ, Mol Res Ctr Childrens Mental Dev, Grad Sch Med, Osaka, Japan

[3] Osaka Univ, Dept Pediat, Grad Sch Med, Osaka, Japan

[4] Univ Tokyo, Int Res Ctr Neurointelligence, Tokyo, Japan

来源：

BRAIN & DEVELOPMENT | 2022年 / 44卷 / 02期

关键词：

Autism spectrum disorders; Atypical audiovisual behavior; Magnetoencephalography; Audiovisual movies; Sensory processing; MULTISENSORY INTEGRATION; CHILDREN; BRAIN; MEG; OSCILLATIONS; FREQUENCY; INSULA; CONNECTIVITY; STIMULATION; ADOLESCENTS;

D O I：

10.1016/j.braindev.2021.08.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Atypical sensory behavior disrupts behavioral adaptation in children with autism spectrum disorder (ASD); however, neural correlates of sensory dysfunction using magnetoencephalography (MEG) remain unclear. Method: We used MEG to measure the cortical activation elicited by visual (uni)/audiovisual (multisensory) movies in 46 children (7-14 years) were included in final analysis: 13 boys with atypical audiovisual behavior in ASD (AAV+), 10 without this condition, and 23 age-matched typically developing boys. Results: The AAV+ group demonstrated an increase in the cortical activation in the bilateral insula in response to unisensory movies and in the left occipital, right superior temporal sulcus (rSTS), and temporal regions to multisensory movies. These increased responses were correlated with severity of the sensory impairment. Increased theta-low gamma oscillations were observed in the rSTS in AAV+. Conclusion: The findings suggest that AAV is attributed to atypical neural networks centered on the rSTS. (C) 2021 The Japanese Society of Child Neurology. Published by Elsevier B.V.

引用

页码：81 / 94

页数：14

共 91 条

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