Two new cyclopentenone metabolites from Streptomyces sp. HU119

被引：0

作者：

Song, Wen-Shuai ^{[1
]}

Qi, Huan ^{[2
]}

Zhang, Shao-Yong ^{[2
]}

Wang, Han ^{[1
]}

Zhang, Cheng-Hong ^{[2
]}

Xiang, Wen-Sheng ^{[1
]}

Wang, Ji-Dong ^{[2
]}

Wang, Xiang-Jing ^{[1
]}

机构：

[1] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin 150030, Peoples R China

[2] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2022年 / 24卷 / 11期

关键词：

Cyclopentenone metabolites; Streptomyces sp; HU119; Tai Lake sediment; structure elucidation;

D O I：

10.1080/10286020.2021.2023505

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two previously undescribed cyclopentenone metabolites, (S)-2-(3-acetylamino-2-methyl)propyl-3-butyl-2-cyclopenten-1-one (1) and (S)-2-(3-acetylamino-2-ethyl)propyl-3-butyl-2-cyclopenten-1-one (2), were isolated from the fermentation broth of the strain Streptomyces sp. HU119. The structures of 1 and 2 were determined by the comprehensive spectroscopic analysis, including 1 D, 2 D NMR, MS spectral analysis and the comparison with data from the literature. The absolute configurations were elucidated by experimental and calculated optical rotations (OR). Compounds 1 and 2 displayed weak cytotoxic activity.

引用

页码：1058 / 1063

页数：6

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