Virus infection induced pulmonary fibrosis

被引：115

作者：

Huang, Wei Jie ^{[1
]}

Tang, Xiao Xiao ^{[1
,2
]}

机构：

[1] Guangzhou Med Univ, Natl Clin Res Ctr Resp Dis, Natl Ctr Resp Med,Guangzhou Inst Resp Hlth, State Key Lab Resp Dis,Affiliated Hosp 1, Guangzhou, Peoples R China

[2] Bioisland, Guangzhou Lab, Guangzhou, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2021年 / 19卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Virus infection; Pulmonary fibrosis; Mechanisms; SARS-CoV-2; Potential anti-fibrotic therapy; ACUTE RESPIRATORY SYNDROME; SYNDROME-CORONAVIRUS INFECTION; INTERSTITIAL LUNG-DISEASE; THIN-SECTION CT; TRANSFORMING GROWTH-FACTOR-BETA-1; AXIS PROTECTS; H5N1; VIRUS; CYTOMEGALOVIRUS; PNEUMONIA; PATHOLOGY;

D O I：

10.1186/s12967-021-03159-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In recent years, the relationship between virus infection and pulmonary fibrosis is getting more and more attention, especially after the outbreak of SARS-CoV-2 in 2019, however, the mechanisms underlying the virus-induced pulmonary fibrosis are not fully understood. Here, we review the relationship between pulmonary fibrosis and several viruses such as Human T-cell leukemia virus (HTLV), Human immunodeficiency virus (HIV), Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Murine gamma-herpesvirus 68 (MHV-68), Influenza virus, Avian influenza virus, Middle East Respiratory Syndrome (MERS)-CoV, Severe acute respiratory syndrome (SARS)-CoV and SARS-CoV-2 as well as the mechanisms underlying the virus infection induced pulmonary fibrosis. This may shed new light on the potential targets for anti-fibrotic therapy to treat pulmonary fibrosis induced by viruses including SARS-CoV-2.

引用

页数：15

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