Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties

被引：34

作者：

Daryadel, Shahla ^{[1
]}

Atmaca, Ufuk ^{[1
,2
]}

Taslimi, Parham ^{[1
]}

Gulcin, Ilhami ^{[1
]}

Celik, Murat ^{[1
]}

机构：

[1] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Oltu Vocat Sch, Erzurum, Turkey

来源：

ARCHIV DER PHARMAZIE | 2018年 / 351卷 / 11期

关键词：

acetylcholinesterase; butyrylcholinesterase; carbonic anhydrase; enzyme inhibition; sulfamate; INCLUDING NATURAL-PRODUCTS; GLUTATHIONE-S-TRANSFERASE; ISOENZYMES I; ACETYLCHOLINE ESTERASE; CRYSTAL-STRUCTURE; 1ST SYNTHESIS; HCA I; BUTYRYLCHOLINESTERASE; BROMOPHENOLS; ANTIOXIDANT;

D O I：

10.1002/ardp.201800209

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sulfamates have a large spectrum of biological activities including enzyme inhibition. Eight sulfamates derived from menthol (2a-h) were synthesized. Also, in the other section of this study, novel sulfamate derivatives of menthol were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase I and II enzymes (hCAs I and II). The newly synthesized novel menthol sulfamate and menthol carbonyl sulfamate derivatives showed K-i values in the range of 34.37 +/- 8.17 to 53.40 +/- 10.61 nM against hCA I, 12.91 +/- 4.57 to 38.67 +/- 6.22 nM against hCA II, 111.17 +/- 52.36 to 522.86 +/- 120.08 nM against AChE, and 50.01 +/- 11.73 to 109.63 +/- 50.08 nM against BChE. As a result, the novel menthol sulfamate and menthol carbonyl sulfamate derivatives can be promising Alzheimer's disease drug candidates and novel hCA I and hCA II enzymes inhibitors.

引用

页数：9

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