The Zebrafish: A Powerful Platform for In Vivo, HTS Drug Discovery

被引：82
作者：
Delvecchio, Chris [1 ]
Tiefenbach, Jens [1 ]
Krause, Henry M. [1 ]
机构：
[1] Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Banting & Best Dept Med Res, Toronto, ON M5S 3E1, Canada
来源：
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES | 2011年 / 9卷 / 04期
关键词：
NUCLEAR RECEPTORS; SMALL MOLECULES; ANTIANGIOGENIC COMPOUNDS; TRANSGENIC ZEBRAFISH; GENE-EXPRESSION; HUMAN-DISEASE; MODEL; TOXICITY; EMBRYOS; IDENTIFICATION;
D O I：
10.1089/adt.2010.0346
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The zebrafish (Danio rerio) is an emerging vertebrate model for drug discovery that permits whole animal drug screens with excellent throughput, combined with ease of use and low cost. This review will begin with a discussion on the background, suitability, and advantages of this vertebrate model system and then, citing specific examples, will describe the utility of zebrafish at specific stages in the drug development pipeline. We will end with a synopsis of recent drug screens based on morphological disruptions, genetic disease models, fluorescent markers, behavioral changes, and specific targets. The numerous advantages of this whole animal approach provide new promise for the discovery of safe, specific, and powerful new drugs.
引用
收藏
页码：354 / 361
页数：8
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