A Double Electrochemical Platform for Ultrasensitive and Simultaneous Determination of 6-Mercaptopurine and Folic Acid Based on a Carbon Paste Electrode Modified with Zno-Cuo Nanoplates and 2-chlorobenzoyl ferrocene

被引：9
作者：
Beitollahi, Hadi [1 ]
Ivari, Susan Ghofrani [2 ]
Torkzadeh-Mahani, Masoud [3 ]
机构：
[1] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Environm Dept, Kerman, Iran
[2] Grad Univ Adv Technol, Dept Chem, Kerman, Iran
[3] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Biotechnol Dept, Kerman, Iran
来源：
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY | 2017年 / 6卷 / 04期
关键词：
SELECTIVE POTENTIOMETRIC SENSOR; POLY(VINYL CHLORIDE) MATRIX; VOLTAMMETRIC DETERMINATION; GRAPHITE ELECTRODE; PVC MATRIX; SPECTROPHOTOMETRIC DETERMINATION; SENSITIVE DETERMINATION; LYMPHOBLASTIC-LEUKEMIA; LIQUID-CHROMATOGRAPHY; MEMBRANE SENSORS;
D O I：
10.1149/2.0201704jss
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
2-chlorobenzoyl ferrocene, was synthesized and used to construct a modified ZnO-CuO nanoplates modified carbon paste electrode. The electrooxidation of 6-mercaptopurine at the surface of the modified electrode was studied. Under the optimized conditions, the square wave voltammetric (SWV) peak current of 6-mercaptopurine increased linearly with 6-mercaptopurine concentration in the range of 0.075 to 10.0 mu M and 10.0 to 500.0 mu M and a detection limit of 0.045 mu M was obtained for 6-mercaptopurine. The diffusion coefficient and kinetic parameters such as electron transfer coefficient for 6-mercaptopurine oxidation were also determined. In addition, this modified electrode was used for simultaneous determination of 6-mercaptopurine and folic acid. Finally, the modified electrode was used for determination of mercaptopurine and folic acid in pharmaceutical and biological samples. (c) 2017 The Electrochemical Society. All rights reserved.
引用
收藏
页码：M29 / M35
页数：7
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