A Double Electrochemical Platform for Ultrasensitive and Simultaneous Determination of 6-Mercaptopurine and Folic Acid Based on a Carbon Paste Electrode Modified with Zno-Cuo Nanoplates and 2-chlorobenzoyl ferrocene

被引：9
作者：
Beitollahi, Hadi [1 ]
Ivari, Susan Ghofrani [2 ]
Torkzadeh-Mahani, Masoud [3 ]
机构：
[1] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Environm Dept, Kerman, Iran
[2] Grad Univ Adv Technol, Dept Chem, Kerman, Iran
[3] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Biotechnol Dept, Kerman, Iran
来源：
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY | 2017年 / 6卷 / 04期
关键词：
SELECTIVE POTENTIOMETRIC SENSOR; POLY(VINYL CHLORIDE) MATRIX; VOLTAMMETRIC DETERMINATION; GRAPHITE ELECTRODE; PVC MATRIX; SPECTROPHOTOMETRIC DETERMINATION; SENSITIVE DETERMINATION; LYMPHOBLASTIC-LEUKEMIA; LIQUID-CHROMATOGRAPHY; MEMBRANE SENSORS;
D O I：
10.1149/2.0201704jss
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
2-chlorobenzoyl ferrocene, was synthesized and used to construct a modified ZnO-CuO nanoplates modified carbon paste electrode. The electrooxidation of 6-mercaptopurine at the surface of the modified electrode was studied. Under the optimized conditions, the square wave voltammetric (SWV) peak current of 6-mercaptopurine increased linearly with 6-mercaptopurine concentration in the range of 0.075 to 10.0 mu M and 10.0 to 500.0 mu M and a detection limit of 0.045 mu M was obtained for 6-mercaptopurine. The diffusion coefficient and kinetic parameters such as electron transfer coefficient for 6-mercaptopurine oxidation were also determined. In addition, this modified electrode was used for simultaneous determination of 6-mercaptopurine and folic acid. Finally, the modified electrode was used for determination of mercaptopurine and folic acid in pharmaceutical and biological samples. (c) 2017 The Electrochemical Society. All rights reserved.
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收藏
页码：M29 / M35
页数：7
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