Increased Expression of T Cell Immunoglobulin and Mucin Domain 4 Is Positively Associated with the Disease Severity of Patients with Ankylosing Spondylitis

被引：11

作者：

Chen, Dongdong ^{[1
]}

He, Jianying ^{[1
]}

Lu, Changchang ^{[1
]}

Zhou, Jihang ^{[1
]}

Fang, Kexin ^{[1
]}

Liu, Xiaoguang ^{[1
]}

Xu, Liyun ^{[1
]}

机构：

[1] Zhoushan Hosp, Cell & Mol Biol Lab, Zhoushan City 316000, Zhejiang Provin, Peoples R China

来源：

INFLAMMATION | 2015年 / 38卷 / 03期

关键词：

ankylosing spondylitis; T cell immunoglobulin and mucin domain 4; tumor necrosis factor alpha; monocyte; HLA-B27; TIM-4; PHOSPHATIDYLSERINE; MACROPHAGES; IMMUNITY;

D O I：

10.1007/s10753-014-0055-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Monocytes and associated cytokines have been shown to be involved in the pathogenesis of ankylosing spondylitis (AS). T cell immunoglobulin and mucin domain 4 (Tim-4) was identified on monocytes/macrophages and dentritic cells (DCs) and plays important roles in regulating the activities of macrophages and DCs. The current study investigated the association between Tim-4 expression and AS. Our results showed that Tim-4 expression on monocytes and Tim-4 level in plasma were highly increased in AS patients than in controls. Furthermore, TNF-alpha production and bath ankylosing spondylitis disease activity index (BASDAI) have positive relationships with Tim-4 expression in AS patients. High expression of Tim-4 was thought to contribute to the pathogenesis and an underlying mechanism of AS.

引用

页码：935 / 940

页数：6

共 18 条

[1] TIM-4 Has Dual Function in the Induction and Effector Phases of Murine Arthritis [J].

Abe, Yoshiyuki ;

Kamachi, Fumitaka ;

Kawamoto, Toshio ;

Makino, Fumihiko ;

Ito, Jun ;

Kojima, Yuko ;

Moustapha, Alaa El Din Hussein ;

Usui, Yoshihiko ;

Yagita, Hideo ;

Takasaki, Yoshinari ;

Okumura, Ko ;

Akiba, Hisaya .

JOURNAL OF IMMUNOLOGY, 2013, 191 (09) :4562-4572

[2] TIM-4, a Receptor for Phosphatidylserine, Controls Adaptive Immunity by Regulating the Removal of Antigen-Specific T Cells [J].

Albacker, Lee A. ;

Karisola, Piia ;

Chang, Ya-Jen ;

Umetsu, Sarah E. ;

Zhou, Meixia ;

Akbari, Omid ;

Kobayashi, Norimoto ;

Baumgarth, Nicole ;

Freeman, Gordon J. ;

Umetsu, Dale T. ;

DeKruyff, Rosemarie H. .

JOURNAL OF IMMUNOLOGY, 2010, 185 (11) :6839-6849

[3]

Ambarus C., 2010, CURRENT OPINION RHEU, V24, P351

[4] Higher Bone Turnover Is Related to Spinal Radiographic Damage and Low Bone Mineral Density in Ankylosing Spondylitis Patients with Active Disease: A Cross-Sectional Analysis [J].

Arends, Suzanne ;

Spoorenberg, Anneke ;

Efde, Monique ;

Bos, Reinhard ;

Leijsma, Martha K. ;

Bootsma, Hendrika ;

Veeger, Nic J. G. M. ;

Brouwer, Elisabeth ;

van der Veer, Eveline .

PLOS ONE, 2014, 9 (06)

[5] T cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis [J].

Khademi, M ;

Illés, Z ;

Gielen, AW ;

Marta, M ;

Takazawa, N ;

Baecher-Allan, C ;

Brundin, L ;

Hannerz, J ;

Martin, C ;

Harris, RA ;

Hafler, DA ;

Kuchroo, VK ;

Olsson, T ;

Piehl, F ;

Wallström, E .

JOURNAL OF IMMUNOLOGY, 2004, 172 (11) :7169-7176

[6] TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells [J].

Kobayashi, Norimoto ;

Karisola, Piia ;

Pena-Cruz, Victor ;

Dorfman, David M. ;

Jinushi, Masahisa ;

Umetsu, Sarah E. ;

Butte, Manish J. ;

Nagumo, Haruo ;

Chernova, Irene ;

Zhu, Baogong ;

Sharpe, Arlene H. ;

Ito, Susumu ;

Dranoff, Glenn ;

Kaplan, Gerardo G. ;

Casasnovas, Jose M. ;

Umetsu, Dale T. ;

Dekruyff, Rosemarie H. ;

Freeman, Gordon J. .

IMMUNITY, 2007, 27 (06) :927-940

[7] The TIM gene family:: Emerging roles in immunity and disease [J].

Kuchroo, VK ;

Umetsu, DT ;

DeKruyff, RH ;

Freeman, GJ .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (06) :454-462

[8] The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity [J].

Li, Zhenhong ;

Ju, Zhongliang ;

Frieri, Marianne .

ALLERGY AND ASTHMA PROCEEDINGS, 2013, 34 (01) :E21-E26

[9]

Ma H, 2013, EUR REV MED PHARMACO, V17, P2798

[10] TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation [J].

Meyers, JH ;

Chakravarti, S ;

Schlesinger, D ;

Illes, Z ;

Waldner, H ;

Umetsu, SE ;

Kenny, J ;

Zheng, XX ;

Umetsu, DT ;

DeKruyff, RH ;

Strom, TB ;

Kuchroo, VK .

NATURE IMMUNOLOGY, 2005, 6 (05) :455-464

← 1 2 →