Two-Dimensional Shear Wave Elastography Evaluation of Post-transplantation Complications in Pediatric Receipt: A Retrospective Cohort

被引:9
作者
Gu, Li-hong [1 ,2 ]
Lv, Zi-cheng [1 ]
Wu, Hao-xiang [1 ]
Hou, Yu-Chen [1 ]
Gao, Run-lin [3 ]
Xi, Zhi-feng [1 ]
Fang, Hua [2 ]
Feng, Hao [1 ,4 ,5 ]
Jiang, Li-xin [2 ]
Xia, Qiang [1 ,4 ,5 ]
机构
[1] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Liver Surg, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Ultrasound, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Pathol, Shanghai, Peoples R China
[4] Shanghai Engn Res Ctr Transplantat & Immunol, Shanghai, Peoples R China
[5] Shanghai Inst Transplantat, Shanghai, Peoples R China
来源
FRONTIERS IN PEDIATRICS | 2022年 / 10卷
基金
中国国家自然科学基金;
关键词
transplantation; two-dimensional shear wave elastography; ultrasound; pediatric; complications (COMP); LIVER FIBROSIS; EFSUMB GUIDELINES; CLINICAL-USE; DIAGNOSTIC-ACCURACY; HEALTHY-SUBJECTS; ULTRASOUND; TRANSPLANTATION; RECOMMENDATIONS; STIFFNESS; HEPATITIS;
D O I
10.3389/fped.2022.918145
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BackgroundThe 20-year survival rate in pediatric patients after liver transplantation (LT) was no more than 70%. Hepatic fibrosis is one of the principal factors affecting the long-term prognosis. Imaging evaluation was the first-line examination for pediatric liver graft assessment. However, the sensitivity and specificity were insufficient. Thus, two-dimensional shear wave elastography (2D-SWE) was performed to evaluate liver graft stiffness and complication in post-transplant pediatric receipt. Materials and MethodsIn this retrospective cohort, 343 pediatric recipients who underwent liver graft biopsy in our tertiary LT center were recruited between June 2018 and December 2020. The 2D-SWE evaluation, laboratory examination, routine post-transplant biopsy, and hepatic pathological assessment were performed. ResultsNinety-eight of the 343 pediatric patients were included according to the protocol. The Liver Stiffness Measurements (LSM) value of 2D-SWE was significantly elevated in post-transplant fibrosis (p < 0.0001). The LSM value of patients with post-transplant biliary complications (p < 0.0001) and biopsy-proven rejection (BPR, p = 0.0016) also rose compared to regular recovery patients. Concerning the sensitivity and specificity of 2D-SWE in diagnosing liver graft fibrosis, the area under the ROC curve (AUC) was 88%, and the optimal cutoff value was 10.3 kPa. ConclusionPediatric LSM by 2D-SWE was efficient. Routine 2D-SWE evaluation could be optimal to predict significant liver graft fibrosis.
引用
收藏
页数:8
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