Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy

被引：3
|
作者：
Shinohara, Yusei [1 ]
Endo, Yoshio [2 ]
Abe, Chiaki [3 ]
Shiba, Ikkyu [1 ]
Ishizuka, Masahiro [4 ]
Tanaka, Tohru [4 ]
Yonemura, Yutaka [5 ]
Ogura, Shun-Ichiro [6 ]
Tominaga, Masahide [7 ]
Yamada, Hisatsugu [8 ]
Uto, Yoshihiro [8 ]
机构：
[1] Tokushima Univ, Grad Sch Adv Technol & Sci, Tokushima, Japan
[2] Kanazawa Univ, Canc Res Inst, Cent Res Resource Branch, Kanazawa, Ishikawa, Japan
[3] Inst Biomed Res & Innovat, Dept Mol Life Sci, Kobe, Hyogo, Japan
[4] SBI Pharmaceut Co Ltd, Tokyo, Japan
[5] NPO Org Support Peritoneal Disseminat Treatment, Osaka, Japan
[6] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Yokohama, Kanagawa, Japan
[7] Tokushima Univ, Grad Sch, Inst Hlth Sci, Tokushima, Japan
[8] Tokushima Univ, Grad Sch, Inst Biosci & Bioind, 2-1 Minamijosanjima Cho, Tokushima 7708506, Japan
来源：
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2017年 / 20卷
关键词：
5-Aminolevulinic acid; Protoporphyrin IX; Photodynamic therapy; Schiff base; ACCUMULATION; EXPRESSION; MEMBRANE; ROLES; ABCG2; PEPT1; ABCB6;
D O I：
10.1016/j.pdpdt.2017.10.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PDX), is now widely used for photodynamic diagnosis (ALA-PDD) and photodynamic therapy (ALA-PDT) of various cancers. Recently, we found that treatment of cancer cells with the Schiff base derivative TX-816 along with ALA could significantly increase the efficacy of ALA-PDT. This enhancing effect of TX-816 on ALA-PDT is attributed to 3,5-dichlorosalicylaldehyde (DCSA), a molecule produced by the degradation of TX-816. Similar to TX-816, DCSA significantly enhances the effect of ALA-PDT. Furthermore, DCSA could restore the sensitivity of cancer cells that acquired resistance to ALA-PDT. These results indicate that DCSA, as well as TX-816, is a potent lead compound for the development of an ALA-PDT sensitizer. TX-816 might be a useful compound for designing prodrug-type ALA-PDT enhancers.
引用
收藏
页码：182 / 188
页数：7
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