Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy

被引：3

作者：

Shinohara, Yusei ^{[1
]}

Endo, Yoshio ^{[2
]}

Abe, Chiaki ^{[3
]}

Shiba, Ikkyu ^{[1
]}

Ishizuka, Masahiro ^{[4
]}

Tanaka, Tohru ^{[4
]}

Yonemura, Yutaka ^{[5
]}

Ogura, Shun-Ichiro ^{[6
]}

Tominaga, Masahide ^{[7
]}

Yamada, Hisatsugu ^{[8
]}

Uto, Yoshihiro ^{[8
]}

机构：

[1] Tokushima Univ, Grad Sch Adv Technol & Sci, Tokushima, Japan

[2] Kanazawa Univ, Canc Res Inst, Cent Res Resource Branch, Kanazawa, Ishikawa, Japan

[3] Inst Biomed Res & Innovat, Dept Mol Life Sci, Kobe, Hyogo, Japan

[4] SBI Pharmaceut Co Ltd, Tokyo, Japan

[5] NPO Org Support Peritoneal Disseminat Treatment, Osaka, Japan

[6] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Yokohama, Kanagawa, Japan

[7] Tokushima Univ, Grad Sch, Inst Hlth Sci, Tokushima, Japan

[8] Tokushima Univ, Grad Sch, Inst Biosci & Bioind, 2-1 Minamijosanjima Cho, Tokushima 7708506, Japan

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2017年 / 20卷

关键词：

5-Aminolevulinic acid; Protoporphyrin IX; Photodynamic therapy; Schiff base; ACCUMULATION; EXPRESSION; MEMBRANE; ROLES; ABCG2; PEPT1; ABCB6;

D O I：

10.1016/j.pdpdt.2017.10.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PDX), is now widely used for photodynamic diagnosis (ALA-PDD) and photodynamic therapy (ALA-PDT) of various cancers. Recently, we found that treatment of cancer cells with the Schiff base derivative TX-816 along with ALA could significantly increase the efficacy of ALA-PDT. This enhancing effect of TX-816 on ALA-PDT is attributed to 3,5-dichlorosalicylaldehyde (DCSA), a molecule produced by the degradation of TX-816. Similar to TX-816, DCSA significantly enhances the effect of ALA-PDT. Furthermore, DCSA could restore the sensitivity of cancer cells that acquired resistance to ALA-PDT. These results indicate that DCSA, as well as TX-816, is a potent lead compound for the development of an ALA-PDT sensitizer. TX-816 might be a useful compound for designing prodrug-type ALA-PDT enhancers.

引用

页码：182 / 188

页数：7

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