Synthetic Biology Approaches to the Sustainable Production of p-Coumaric Acid and Its Derivatives in Cyanobacteria

被引：2

作者：

Xue, Yong ^{[1
]}

He, Qingfang ^{[2
]}

机构：

[1] US FDA, Div Microbiol, Ctr Food Safety & Appl Nutr, College Pk, MD USA

[2] Univ Arkansas, Dept Biol, Little Rock, AR 72204 USA

来源：

SYNTHETIC BIOLOGY OF CYANOBACTERIA | 2018年 / 1080卷

关键词：

Secondary metabolites; Phenylpropanoid; p-Coumaric acid; Caffeic acid; Cyanobacteria; Laccase; P450; proteins; HIGH-LEVEL EXPRESSION; SP PCC 6803; CAFFEIC ACID; ESCHERICHIA-COLI; BIOSYNTHESIS; PATHWAY; GENES; ENZYME; CYTOCHROME-P450; CONSTRUCTION;

D O I：

10.1007/978-981-13-0854-3_11

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The photosynthetic cyanobacteria are promising candidates for the sustainable production of a plethora of plant secondary metabolites, which are beneficial to human health but are difficult to produce and purify in other systems. This chapter focuses on genetic engineering of Synechocystis PCC 6803 for production of p-coumaric acid and its derivatives. Cyanobacterial engineering approaches are briefly reviewed. Strategies to increase production yield are discussed, including codon optimization of genes expressing enzymatic proteins and a laccase-coding gene knockout from Synechocystis genome which degrades polyphenols.

引用

页码：261 / 277

页数：17

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