New generation drugs for treatment of multiple myeloma

被引：37

作者：

Alanazi, Fehaid ^{[1
]}

Kwa, Faith A. A. ^{[1
]}

Burchall, Genia ^{[1
]}

Jackson, Denise E. ^{[1
]}

机构：

[1] RMIT Univ, Sch Hlth & Biomed Sci, Thrombosis & Vasc Dis Lab, Melbourne, Vic, Australia

来源：

DRUG DISCOVERY TODAY | 2020年 / 25卷 / 02期

关键词：

RISK-FACTORS; PROTEASOME INHIBITORS; DARATUMUMAB MONOTHERAPY; IMMUNOMODULATORY DRUGS; VENOUS THROMBOEMBOLISM; COMBINATION TREATMENTS; PLASMA-CELLS; OPEN-LABEL; T-CELLS; DEXAMETHASONE;

D O I：

10.1016/j.drudis.2019.11.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Multiple myeloma (MM), a plasma cell malignancy, is characterised by lesions in multiple bones involving transformed, matured post-follicular B cells. The course of the disease involves an initial development of monoclonal gammopathy of undetermined significance (MGUS), followed by smouldering MM, before the full MM disease emerges. Despite novel therapies, MM remains incurable, managed by combination therapies, including proteasome inhibitors (PIs), immunomodulators (IMiDs) and anti-human CD38 (daratumumab). MM patients have an increased risk of thromboembolic events due to combination treatments with IMiDs, PIs and anti-human CD38 antibody, and steroids. This review will examine the efficacy and pro-thrombotic effects of MM therapies.

引用

页码：367 / 379

页数：13

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