Development of novel sustained release bioadhesive vaginal tablets of povidone iodine

被引:14
作者
Garg, Sanjay [1 ]
Jambu, Lavit [2 ]
Vermani, Kavita
机构
[1] Univ Auckland, Fac Med & Hlth Sci, Sch Pharm, Auckland 1, New Zealand
[2] NIPER, Dept Pharmaceut, Mohali, Punjab, India
关键词
vaginal delivery; iodophores; bioadhesive; sustained release;
D O I
10.1080/03639040701385782
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Iodine has long been used as an antiseptic for the prevention and treatment of vaginal infections. The present study was aimed at the development of rapidly disintegrating, bioadhesive and sustained release vaginal tablets of an iodophore, polyvinylpyrrolidone (povidone iodine), their evaluation and comparison with the marketed formulations. The formulation development included drug-excipient compatibility studies, optimization of performance parameters like disintegration time, bioadhesion and drug release profile and comparison of physical properties and performance parameters with the marketed formulation. The developed formulation provided a sustained release of polymer complexed iodine (up to 8 hrs), rapid disintegration (< 1 min.), desired bioadhesive properties and retention for a prolonged time.
引用
收藏
页码:1340 / 1349
页数:10
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