Decreased expression of Zwint-1 is associated with poor prognosis in hepatocellular carcinoma

被引：1

作者：

Wang, Hui-Ju ^{[1
,6
]}

Wang, Liang ^{[2
]}

Lv, Jia ^{[1
,4
]}

Fu, Luo-Qin ^{[1
]}

Wang, Zhen ^{[1
]}

He, Xiang-Lei ^{[3
]}

Ma, Ying-Yu ^{[1
,6
]}

Li, Li ^{[1
,6
]}

Zhao, Tong-Wei ^{[5
]}

Xu, Xiao-Gang ^{[7
]}

Yu, Li-Li ^{[3
]}

Pan, Hong-Ying ^{[1
]}

Hu, Zhi-Ming ^{[1
,4
]}

Mou, Xiao-Zhou ^{[1
,8
]}

机构：

[1] Peoples Hosp, Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Clin Res Inst, Hangzhou, Zhejiang, Peoples R China

[2] Peoples Hosp, Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Dept Hand Surg, Hangzhou, Zhejiang, Peoples R China

[3] Peoples Hosp, Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Dept Pathol, Hangzhou, Zhejiang, Peoples R China

[4] Peoples Hosp, Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Dept Hepatobiliary & Pancreat Surg, Hangzhou, Zhejiang, Peoples R China

[5] Peoples Hosp, Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Dept Med Oncol, Hangzhou, Zhejiang, Peoples R China

[6] Key Lab Gastroenterol Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China

[7] Zhejiang Univ, Coll Anim Sci, Inst Feed Sci, Key Lab Mol Anim Nutr,Minist Educ, Hangzhou, Zhejiang, Peoples R China

[8] Hangzhou Med Coll, Sch Basic Med Sci, Hangzhou, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2017年 / 10卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Zwint-1; hepatocellular carcinoma; kinetochore; CHROMOSOMAL INSTABILITY; MITOTIC CHECKPOINT; DISEASE BURDEN; KINETOCHORE; CANCER; METAANALYSIS; ANEUPLOIDY; BINDING; HZW10; ZW10;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and aim: ZW10 interacting kinetochore protein 1 (Zwint-1), one of the major kinetochore proteins, is essential for kinetochore function, such as spindle assembly checkpoint function and kinetochore-microtubule attachment. Recently, it has been found over-expressed in some human cancers, including ovarian cancer, bladder cancer, and pulmonary adenocarcinoma. However, few studies of the expression of Zwint-1 in hepatocellular carcinoma (HCC) have been reported. This study is aimed to investigate the expression of Zwint-1 and its relationship with clinical pathological characters in HCC. Methods: The expression of Zwint-1 protein was analyzed by immunohistochemistry staining on tissue microarrays containing 171 HCC tissues and 187 control non-tumorous liver tissues. The relationships between the Zwint-1 expression and the clinicopathological parameters, and survival analysis were investigated using SPSS software 13.0. Results: Zwint-1 was found uniformly expressed in adjacent non-tumorous liver tissues (184/187, 98.40%), while was significantly decreased in HCC tissues, or even absent (150 of 171, 61.82%, P<0.001). The expression of Zwint-1 was negatively associated with age, tumor size, and Edmondson Grade. Besides, HCC patients with low Zwint-1 expression were also correlated with poor overall survival of the patients. Conclusions: Decreased expression of Zwint-1 was associated with poor prognosis in HCC.

引用

页码：10406 / 10412

页数：7

共 30 条

[1] The conserved KMN network constitutes the core microtubule-binding site of the kinetochore [J].