SARS-CoV-2 Neutralizing Antibodies in Chile after a Vaccination Campaign with Five Different Schemes

被引：4

作者：

Aguilera, Ximena ^{[1
]}

Hormazabal, Juan ^{[2
]}

Vial, Cecilia ^{[2
]}

Jimena Cortes, Lina ^{[2
]}

Gonzalez, Claudia ^{[1
]}

Rubilar, Paola ^{[1
]}

Apablaza, Mauricio ^{[3
]}

Ramirez-Santana, Muriel ^{[4
]}

Icaza, Gloria ^{[5
]}

Nunez-Franz, Loreto ^{[6
]}

Castillo-Laborde, Carla ^{[1
]}

Ramirez-Riffo, Carolina ^{[2
]}

Perez, Claudia ^{[7
]}

Quezada-Gate, Ruben ^{[4
]}

Said, Macarena ^{[6
]}

Vial, Pablo ^{[2
,8
]}

机构：

[1] Clin Alemana Univ Desarrollo, Ctr Epidemiol & Polit Salud, Fac Med, Av Plaza 680, Santiago 7610658, Chile

[2] Clin Alemana Univ Desarrollo, Inst Ciencias & Innovac Med, Fac Med, Av Plaza 680, Santiago 7610658, Chile

[3] Univ Desarrollo, Fac Gobierno, Av Plaza 680, Santiago 7610658, Chile

[4] Univ Catolica Norte, Fac Med, Publ Hlth Dept, Larrondo 1281, Coquimbo 1780000, Chile

[5] Univ Talca, Inst Matemat, Ave Uno Poniente 1141, Talca 3460000, Chile

[6] Univ Talca, Fac Ciencias Salud, Dept Salud Publ, Ave Uno Poniente 1141, Talca 3460000, Chile

[7] Clin Alemana Univ Desarrollo, Fac Med, Escuela Enfermeria, Av Plaza 680, Santiago 7610658, Chile

[8] Clin Alemana Santiago, Ave Vitacura 5951, Santiago 7650568, Chile

来源：

VACCINES | 2022年 / 10卷 / 07期

关键词：

neutralizing antibodies; vaccines; BNT162b2; CoronaVac; AZD1222; COVID-19; SARS-CoV-2; cross-sectional design; vaccine-preventable diseases; viruses; COVID-19; VACCINES; BNT162B2;

D O I：

10.3390/vaccines10071051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using levels of neutralizing antibodies (nAbs), we evaluate the successful Chilean SARS-CoV-2 vaccine campaign, which combines different vaccine technologies and heterologous boosters. From a population-based study performed in November 2021, we randomly selected 120 seropositive individuals, organized into six groups of positive samples (20 subjects each) according to natural infection history and the five most frequent vaccination schemes. We conclude that the booster dose, regardless of vaccine technology or natural infection, and mRNA vaccines significantly improve nAbs response.

引用

页数：7

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