Systemic oxidative stress associates with new-onset hypertension in the general population

被引:20
作者
Bourgonje, Arno R. [1 ]
Bourgonje, Martin F. [2 ]
Post, Adrian [3 ]
la Bastide-van Gemert, Sacha [4 ]
Kieneker, Lyanne M. [3 ]
Bulthuis, Marian L. C. [2 ]
Gordijn, Sanne J. [5 ]
Gansevoort, Ron T. [3 ]
Bakker, Stephan J. L. [3 ]
Mulder, Douwe J. [6 ]
Pasch, Andreas [7 ]
van Goor, Harry [2 ]
Abdulle, Amaal E. [6 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
[5] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Groningen, Netherlands
[6] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Vasc Med, Groningen, Netherlands
[7] Johannes Kepler Univ Linz, Inst Physiol & Pathophysiol, Linz, Austria
关键词
Oxidative stress; Redox; Free thiols; Sulfur; Hypertension; Population; CARDIOVASCULAR RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; LIFE-STYLE; GLUTATHIONE; MICROALBUMINURIA; PREVENTION; PLASMA; THIOLS;
D O I
10.1016/j.freeradbiomed.2022.05.020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Oxidative stress is known to be involved in the development of hypertension, but accurate redox biomarkers predicting the risk of developing hypertension are scarce. Serum free sulfhydryl groups (R-SH, free thiols) have been shown to accurately reflect systemic oxidative stress in various conditions. In this study, we aimed to investigate associations between serum free thiols and the risk of developing new-onset hypertension in a population-based cohort study.Methods: Subjects (n = 3,575) who participated in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) study, a prospective, population-based cohort study in the Netherlands, were included. Baseline protein-adjusted serum free thiols were studied for their associations with the development of hypertension, defined as a systolic blood pressure (SBP) of at least 140 mmHg, a diastolic blood pressure (DBP) of at least 90 mmHg, or the first usage of antihypertensive medication. Subjects with hypertension at baseline were excluded from the study.Results: Mean protein-adjusted serum free thiols at baseline was 5.16 mu mol/g of protein (range: 1.62-8.41 mu mol/ g). Protein-adjusted serum free thiols were significantly associated with the risk of incident hypertension (hazard ratio [HR] per doubling 0.60 [95% confidence interval [CI]: 0.49-0.72, P < 0.001), also after adjustment for age and sex (HR 0.81 [95% CI: 0.66-0.91], P < 0.05), but not after additional adjustment for relevant confounding factors (HR 0.90 [95% CI: 0.70-1.15], P = 0.382).Conclusion: Higher levels of serum free thiols, i.e. less oxidative stress, are associated with a decreased risk of developing incident hypertension in subjects from the general population.
引用
收藏
页码:123 / 131
页数:9
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