The immune-metabolic regulatory roles of epoxyeicosatrienoic acids on macrophages phenotypic plasticity in obesity-related insulin resistance

被引：4

作者：

Dai, Meiyan ^{[1
,2
]}

Wu, Lujin ^{[1
,2
]}

Tu, Ling ^{[3
]}

Xu, Xizhen ^{[1
,2
]}

Wang, Dao Wen ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Div Cardiol,Dept Internal Med, Wuhan 430030, Hubei, Peoples R China

[2] Hubei Key Lab Genet & Mol Mech Cardiol Disorders, Wuhan 430030, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Geriatr Med, Wuhan 430030, Hubei, Peoples R China

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2018年 / 139卷

关键词：

Epoxyeicosatrienoic acids; Macrophage polarization; Inflammation; Insulin resistance; SOLUBLE EPOXIDE HYDROLASE; ADIPOSE-TISSUE MACROPHAGES; NECROSIS-FACTOR-ALPHA; BODY-MASS INDEX; HIGH-FAT DIET; CYTOCHROME-P450 EPOXYGENASE CYP2J2; ENDOPLASMIC-RETICULUM STRESS; TARGETED DISRUPTION; EXPRESSION; RISK;

D O I：

10.1016/j.prostaglandins.2018.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages in adipose tissue are associated with obesity-induced low-grade inflammation, which contributed to insulin resistance and the related metabolic diseases. Macrophages display phenotypic plasticity, and polarize under the condition of obesity. Epoxyeicosatrienoic Acids (EETs) are lipid mediators that are involved in the regulation of inflammatory cascades and glucose homeostasis. In this mini-review, we briefly summarize the macrophages recruitment, infiltration and polarization in obese mice, and also discuss the immune-metabolic regulatory role of EETs in this process (See Fig. 1).

引用

页码：36 / 40

页数：5

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