Systemic Markers of Interferon-γ-Mediated Immune Activation and Long-Term Prognosis in Patients With Stable Coronary Artery Disease

被引:118
作者
Pedersen, Eva Ringdal [1 ]
Midttun, Oivind [5 ]
Ueland, Per Magne [2 ,6 ]
Schartum-Hansen, Hall [1 ,4 ]
Seifert, Reinhard [7 ]
Igland, Jannicke [3 ]
Nordrehaug, Jan Erik [1 ,7 ]
Ebbing, Marta [7 ]
Svingen, Gard [7 ]
Bleie, Oyvind [7 ]
Berge, Rolf [1 ,4 ,7 ]
Nygard, Ottar [1 ,4 ,7 ]
机构
[1] Univ Bergen, Inst Med, Cardiol Sect, N-5021 Bergen, Norway
[2] Univ Bergen, Pharmacol Sect, Inst Med, N-5021 Bergen, Norway
[3] Univ Bergen, Inst Publ Hlth & Primary Hlth Care, N-5021 Bergen, Norway
[4] Univ Bergen, Nord Ctr Excellence Human Nutr MitoHlth, N-5021 Bergen, Norway
[5] Bevital AS, Bergen, Norway
[6] Haukeland Hosp, Lab Clin Biochem, N-5021 Bergen, Norway
[7] Haukeland Hosp, Dept Heart Dis, N-5021 Bergen, Norway
关键词
angina pectoris; epidemiology; immune system; risk factors; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; TRYPTOPHAN-METABOLISM; SERUM NEOPTERIN; INFLAMMATION; ATHEROSCLEROSIS; ATHEROGENESIS; DEGRADATION; EXPRESSION; BIOMARKERS;
D O I
10.1161/ATVBAHA.110.219329
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-Interferon gamma (IFN-gamma) is centrally involved in atherosclerosis-related inflammation, but its activity cannot be reliably assessed by systemic measurements. In activated macrophages, IFN-gamma stimulates production of neopterin and conversion of tryptophan to kynurenine. We evaluated the relationships of plasma neopterin and plasma kyunernine: tryptophan ratio (KTR) to long-term prognosis in patients with stable angina pectoris and angiographically verified significant coronary artery disease. Methods and Results-Samples were obtained from 2380 patients with a mean age of 63.7 years; 77.3% were men. During a median follow-up of 56 months, 10.8% of patients experienced a major coronary event (MCE), and 9.5% died. For MCE, each SD increment of neopterin and KTR (logarithmically transformed) was associated with multivariable adjusted hazard ratios and 95% CIs of 1.28 (1.10 to 1.48) and 1.28 (1.12 to 1.48), respectively. The corresponding hazard ratios (95% CIs) for all-cause mortality were 1.40 (1.21 to 1.62) (neopterin) and 1.23 (1.06 to 1.43) (KTR). Conclusion-In patients with stable angina pectoris, systemic markers of IFN-gamma activity, plasma neopterin, and plasma KTR provide similar risk estimates for MCE and mortality. Our results support experimental data linking IFN-gamma to acute atherosclerotic complications. (Arterioscler Thromb Vasc Biol. 2011;31:698-704.)
引用
收藏
页码:698 / 704
页数:7
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