Antibody-Mediated Complement C3b/iC3b Binding to Group B Streptococcus in Paired Mother and Baby Serum Samples in a Refugee Population on the Thailand-Myanmar Border

被引：3

作者：

Herbert, Jenny ^{[1
]}

Thomas, Stephen ^{[1
]}

Brookes, Charlotte ^{[1
]}

Turner, Claudia ^{[2
,3
,4
]}

Turner, Paul ^{[2
,3
,4
]}

Nosten, Francois ^{[2
,3
]}

Le Doare, Kirsty ^{[5
,6
,7
]}

Hudson, Michael ^{[1
]}

Heath, Paul T. ^{[6
,7
]}

Gorringe, Andrew ^{[1
]}

Taylor, Stephen ^{[1
]}

机构：

[1] Publ Hlth England, Salisbury, Wilts, England

[2] Univ Oxford, Nuffield Dept Med, Ctr Trop Med, Oxford, England

[3] Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand

[4] Angkor Hosp Children, Cambodia Oxford Med Res Unit, Siem Reap, Cambodia

[5] Univ London Imperial Coll Sci Technol & Med, Wellcome Ctr Global Hlth Res, London, England

[6] Univ London, Inst Infect & Immun, Paediat Infect Dis Res Grp, London, England

[7] Univ London, Inst Infect & Immun, Vaccine Inst, London, England

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2015年 / 22卷 / 03期

基金：

英国惠康基金;

关键词：

OPSONOPHAGOCYTOSIS ASSAY; CONJUGATE VACCINES; FLOW-CYTOMETRY; CAPSULAR POLYSACCHARIDES; PNEUMOCOCCAL ANTIBODIES; SEROTYPE DISTRIBUTION; FUNCTIONAL-ACTIVITY; III POLYSACCHARIDE; IMMUNE-RESPONSE; DISEASE;

D O I：

10.1128/CVI.00803-14

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal sepsis and meningitis. In this study, we determined antibody-mediated deposition of complement C3b/iC3b onto the bacterial cell surface of GBS serotypes Ia, Ib, II, III, and V. This was determined for 520 mother and umbilical cord serum sample pairs obtained at the time of birth from a population on the Thailand-Myanmar border. Antibody-mediated deposition of complement C3b/iC3b was detected to at least one serotype in 91% of mothers, despite a known carriage rate in this population of only 12%. Antibody-mediated C3b/iC3b deposition corresponded to known carriage rates, with the highest levels of complement deposition observed onto the most prevalent serotype (serotype II) followed by serotypes Ia, III, V, and Ib. Finally, neonates born to mothers carrying serotype II GBS at the time of birth showed higher antibody-mediated C3b/iC3b deposition against serotype II GBS than neonates born to mothers with no serotype II carriage. Assessment of antibody-mediated C3b/iC3b deposition against GBS may provide insights into the seroepidemiology of anti-GBS antibodies in mothers and infants in different populations.

引用

页码：319 / 326

页数：8

共 45 条

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