Mycophenolate mofetil therapy for lupus nephritis refractory to intravenous cyclophosphamide

被引：117
作者：
Glicklich, D [1 ]
Acharya, A [1 ]
机构：
[1] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Div Renal, Bronx, NY 10467 USA
来源：
AMERICAN JOURNAL OF KIDNEY DISEASES | 1998年 / 32卷 / 02期
关键词：
lupus nephritis; cyclophosphamide; mycophenolate mofetil;
D O I：
10.1053/ajkd.1998.v32.pm9708620
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
intravenous (IV) cyclophosphamide has been the treatment of choice for diffuse proliferative glomerulonephritis (DPGN) in patients with systemic lupus erythematosus (SLE), However, there is little guidance in the medical literature about what to do when this therapy fails. Mycophenolate mofetil (MMF), a new immunosuppressive agent, has been used successfully in patients with solid organ transplants and rheumatoid arthritis. We report two patients with diffuse proliferative glomerulonephritis who responded favorably to MMF therapy after IV cyclophosphamide failed. (C) 1998 by the National Kidney Foundation, Inc.
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收藏
页码：318 / 322
页数：5
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