Low-Grade Ductal Carcinoma In Situ and Invasive Mammary Carcinoma With Columnar Cell Morphology Arising in a Complex Fibroadenoma in Continuity With Columnar Cell Change and Flat Epithelial Atypia

被引:3
作者
Petersson, Fredrik [1 ]
Tan, Puay Hoon [2 ]
Putti, Thomas Choudary
机构
[1] Natl Univ Hlth Syst, Dept Pathol, Singapore 119074, Singapore
[2] Singapore Gen Hosp, Singapore 0316, Singapore
关键词
carcinoma; fibroadenoma; flat epithelial atypia; columnar cell change; columnar cell atypia; MICROGLANDULAR ADENOSIS; TUBULAR CARCINOMA; PATHOLOGICAL FEATURES; LOBULAR CARCINOMA; BREAST; LESIONS; CLASSIFICATION; NEOPLASIA;
D O I
10.1177/1066896910373096
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
We describe the clinicopathologic features of a small low-grade invasive mammary carcinoma with cytomorphological columnar cell features arising in a complex fibroadenoma that in addition to sclerosing adenosis, apocrine metaplasia, and usual ductal hyperplasia also displayed columnar cell change with flat epithelial atypia and low-grade ductal carcinoma in situ merging with the invasive carcinoma. There were strong cytomorphological similarities between the invasive carcinoma and the low-grade ductal carcinoma in situ, which also showed significant overlap in the immunohistochemical findings.
引用
收藏
页码:352 / 357
页数:6
相关论文
共 26 条
[1]   High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma [J].
Abdel-Fatah, Tarek M. A. ;
Powe, Desmond G. ;
Hodi, Zsolt ;
Lee, Andrew H. S. ;
Reis-Filho, Jorge S. ;
Ellis, Ian O. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2007, 31 (03) :417-426
[2]  
Blanco Mario, 2005, Ann Diagn Pathol, V9, P157, DOI 10.1016/j.anndiagpath.2005.02.008
[3]  
Charfi L, 2008, PATHOLOGICA, V100, P199
[4]   MICROGLANDULAR ADENOSIS OF THE BREAST - A LESION SIMULATING TUBULAR CARCINOMA [J].
CLEMENT, PB ;
AZZOPARDI, JG .
HISTOPATHOLOGY, 1983, 7 (02) :169-180
[5]   Clinical and pathologic features of ductal carcinoma in situ associated with the presence of flat epithelial atypia:: an analysis of 543 patients [J].
Collins, Laura C. ;
Achacoso, Ninah A. ;
Nekhlyudov, Larissa ;
Fletcher, Suzanne W. ;
Haque, Reina ;
Quesenberry, Charles P., Jr. ;
Alshak, Najeeb S. ;
Puligandla, Balaram ;
Brodsky, Gilbert L. ;
Schnitt, Stuart J. ;
Habel, Laurel A. .
MODERN PATHOLOGY, 2007, 20 (11) :1149-1155
[6]   Intracystic papillary carcinomas of the breast: A reevaluation using a panel of myoepithelial cell markers [J].
Collins, Laura C. ;
Carlo, Victor P. ;
Hwang, Harry ;
Barry, Todd S. ;
Gown, Allen M. ;
Schnitt, Stuart J. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2006, 30 (08) :1002-1007
[7]  
Corben Adriana D, 2009, Surg Pathol Clin, V2, P351, DOI 10.1016/j.path.2009.02.003
[8]   CARCINOMA ARISING WITHIN FIBROADENOMAS OF THE BREAST - A CLINICOPATHOLOGICAL STUDY OF 105 PATIENTS [J].
DIAZ, NM ;
PALMER, JO ;
MCDIVITT, RW .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1991, 95 (05) :614-622
[9]  
FONDO EY, 1979, CANCER-AM CANCER SOC, V43, P563, DOI 10.1002/1097-0142(197902)43:2<563::AID-CNCR2820430224>3.0.CO
[10]  
2-H