Copper Aluminate Spinel in Click Chemistry: An Efficient Heterogeneous Nanocatalyst for the Highly Regioselective Synthesis of Triazoles in Water

被引：21

作者：

Khalili, Dariush ^{[1
]}

Kavoosi, Leila ^{[1
]}

Khalafi-Nezhad, Ali ^{[1
]}

机构：

[1] Shiraz Univ, Dept Chem, Coll Sci, Shiraz 71454, Iran

来源：

SYNLETT | 2019年 / 30卷 / 19期

关键词：

click chemistry; copper catalysis; triazoles; epoxides; azides; alkynes; CYCLOADDITION; CATALYST; LIGAND; CUAAC; CU; 1,2,3-TRIAZOLES; NANOPARTICLES; DERIVATIVES; CUAL2O4; IODIDE;

D O I：

10.1055/s-0039-1690719

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expeditious protocol for the one-pot synthesis of 1,4-disubstituted (beta-hydroxy)-1,2,3-triazoles in an aqueous medium has been developed using copper aluminate nanoparticles. This heterogeneous catalytic system was found to drive a multicomponent click reaction between organic azides (generated in situ from epoxides or halides) and terminal aliphatic or aromatic alkynes in up to 96% yield without the need for a reducing agent. Structurally diverse 1,2,3-triazoles were synthesized in good to excellent yields, and the catalyst could be easily separated by simple filtration, recycled, and reused in six subsequent cycles.

引用

页码：2136 / 2142

页数：7

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