Histological and immunohistochemical characterization of feline renal cell carcinoma: a case series

被引：8
作者：
Bonsembiante, Federico [1 ]
Benali, Silvia Lucia [1 ]
Trez, Davide [1 ]
Aresu, Luca [1 ]
Gelain, Maria Elena [1 ]
机构：
[1] Univ Padua, Dept Comparat Biomed & Food Sci, Viale Univ 16, Legnaro, PD, Italy
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2016年 / 78卷 / 06期
关键词：
cat; immunohistochemistry; renal cell carcinoma; EPITHELIAL-MESENCHYMAL TRANSITION; INTERMEDIATE-FILAMENT PROTEINS; DISTRIBUTION PATTERN; MAMMARY-TUMORS; EXPRESSION; NEOPLASMS; CAT; CLASSIFICATION; DIAGNOSIS;
D O I：
10.1292/jvms.15-0697
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Four feline renal cell carcinomas (RCCs) were examined using histopathological and immunohistochemical procedures. Specimens were classified by predominant histological pattern according to WHO criteria. A panel of antibodies including beta-catenin, C-KIT, VEGF and VEGF-R2 and double immunostaining for vimentin/cytokeratin and for E-cadherin/CD10 was selected to characterize the tumors. Neoplasms were classified as tubular (3/4) and papillary (1/4). Neoplastic epithelial cells were cytokeratin, vimentin, E-cadherin, VEGF-R2 positive and C-KIT negative; 3 cases were beta-catenin positive, whereas only 2 tumors were CD10 and VEGF positive. No correlation with histotype was evident. Our results confirm the low frequency of RCCs in cats and suggest a histological pattern similar to canine RCCs. In contrast, a peculiar immunohistochemical profile different from both canine and human RCCs is identified.
引用
收藏
页码：1039 / 1043
页数：5
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