Electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in the injured spinal cord of adult rats

被引：10

作者：

Wu, Haiying ^{[1
,2
,4
]}

Hu, Min ^{[3
]}

Yuan, Dekai ^{[3
]}

Wu, Haiying ^{[1
,2
,4
]}

Wang, Yunhui ^{[1
,2
]}

Wang, Jing ^{[1
,2
]}

Li, Tao ^{[1
,2
]}

Qian, Chuanyun ^{[1
,2
]}

Yu, Hualin ^{[5
]}

机构：

[1] Kunming Med Coll, Dept Emergency, Affiliated Hosp 1, Kunming 650032, Yunnan Province, Peoples R China

[2] Kunming Med Coll, Intens Care Unit, Affiliated Hosp 1, Kunming 650032, Yunnan Province, Peoples R China

[3] Kunming Univ, Kunming 650118, Yunnan Province, Peoples R China

[4] Kunming Med Coll, Affiliated Hosp 2, Dept Otolaryngol, Kunming 650101, Yunnan Province, Peoples R China

[5] Kunming Med Coll, Affiliated Hosp 1, Dept Minimally Invas Neurosurg, Kunming 650032, Yunnan Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 15期

基金：

中国国家自然科学基金;

关键词：

endogenous oligodendrocyte progenitor cells; spinal cord injury; electroacupuncture; proliferation; remyelination; neural regeneration; PROGENITOR CELLS; ELECTRICAL-STIMULATION; REMYELINATION; DEMYELINATION; DIFFERENTIATION; MYELINATION; RELEASE; NEURONS; MODELS; REPAIR;

D O I：

10.3969/j.issn.1673-5374.2012.15.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A contusive model of spinal cord injury at spinal segment T8-9 was established in rats. Huantiao (GB30) and Huatuojiaji (Ex-B05) were punctured with needles, and endogenous neural stem cells were labeled with 5-bromo-2'-deoxyuridine (BrdU) and NG2. Double immunofluorescence staining showed that electroacupuncture markedly increased the numbers of BrdU(+)/NG2(+) cells at spinal cord tissue 15 mm away from the injury center in the rostral and caudal directions. The results suggest that electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in rats with spinal cord injury.

引用

页码：1138 / 1144

页数：7

共 31 条

[31] Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury [J].

Yang, H ;

Lu, P ;

McKay, HM ;

Bernot, T ;

Keirstead, H ;

Steward, O ;

Gage, FH ;

Edgerton, VR ;

Tuszynski, MH .

JOURNAL OF NEUROSCIENCE, 2006, 26 (08) :2157-2166

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