Nano toolbox in immune modulation and nanovaccines

被引:44
作者
Azharuddin, Mohammad [1 ,4 ]
Zhu, Geyunjian Harry
Sengupta, Anirban [1 ]
Hinkula, Jorma [1 ]
Slater, Nigel K. H. [2 ]
Patra, Hirak K. [3 ]
机构
[1] Linkoping Univ, Dept Biomed & Clin Sci BKV, Linkoping, Sweden
[2] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England
[3] UCL, Dept Surg Biotechnol, London, England
[4] Cambridge Display Technol, Godmanchester, England
基金
英国医学研究理事会;
关键词
DENDRITIC CELLS; GOLD NANOPARTICLES; VACCINE DELIVERY; CROSS-PRESENTATION; PATHOGEN RECOGNITION; BACTERIAL FLAGELLIN; ANTITUMOR IMMUNITY; INFLUENZA VACCINE; ANTIGEN DELIVERY; RATIONAL DESIGN;
D O I
10.1016/j.tibtech.2022.03.011
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Despite the great success of vaccines over two centuries, the conventional strategy is based on attenuated/altered microorganisms. However, this is not effective for all microbes and often fails to elicit a protective immune response, and sometimes poses unexpected safety risks. The expanding nano toolbox may overcome some of the roadblocks in vaccine development given the plethora of unique nanoparticle (NP)-based platforms that can successfully induce specific immune responses leading to exciting and novel solutions. Nanovaccines necessitate a thorough understanding of the immunostimulatory effect of these nanotools. We present a comprehensive description of strategies in which nanotools have been used to elicit an immune response and provide a perspective on how nanotechnology can lead to future personalized nanovaccines.
引用
收藏
页码:1195 / 1212
页数:18
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