Blood clots and TAM receptor signalling in COVID-19 pathogenesis

被引：44

作者：

Lemke, Greg ^{[1
,2
]}

Silverman, Gregg J. ^{[3
]}

机构：

[1] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA

[2] Salk Inst Biol Studies, Immunobiol & Microbial Pathogenesis Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

[3] NYU, Sch Med, Dept Med, Lab Cell Immunobiol B, New York, NY 10003 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 07期

关键词：

COAGULATION;

D O I：

10.1038/s41577-020-0354-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We suggest that the exuberant blood clotting and immune hyper-reaction seen in patients with COVID-19 may be exacerbated by depletion of the same regulator. This agent is protein S, which is both an anticoagulant in the blood coagulation cascade and an activating ligand for the immunosuppressive TAM family of receptor tyrosine kinases.

引用

收藏

页码：395 / 396

页数：2

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