Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes

被引：135

作者：

Green, Richard E. ^{[1
,2
]}

Lewis, Benjamin P. ^{[1
,3
]}

Hillman, R. Tyler ^{[1
]}

Blanchette, Marco ^{[2
]}

Lareau, Liana F. ^{[2
]}

Garnett, Aaron T. ^{[2
]}

Rio, Donald C. ^{[2
]}

Brenner, Steven E. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Biophys Grad Grp, Berkeley, CA 94720 USA

来源：

BIOINFORMATICS | 2003年 / 19卷

关键词：

D O I：

10.1093/bioinformatics/btg1015

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have recently shown that a third of reliably-inferred alternative mRNA isoforms are candidates for nonsense-mediated mRNA decay (NMD), an mRNA surveillance system (Lewis et al., 2003, Proc. Natl Acad. Sci. USA, 100, 189-192). Rather than being translated to yield protein, these transcripts are expected to be degraded and may be subject to regulated unproductive splicing and translation (RUST). Our initial experimental studies are consistent with these predictions and suggest an unappreciated role for NMD in several human diseases.

引用

页码：i118 / i121

页数：4

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