Combined treatment of aggressive central giant cell granuloma in the lower jaw

被引:27
作者
Rachmiel, Adi [1 ,3 ]
Emodi, Omri [1 ]
Sabo, Edmond [2 ,3 ]
Aizenbud, Dror [1 ,3 ]
Peled, Micha [1 ,3 ]
机构
[1] Rambam Med Ctr, Dept Oral & Maxillofacial Surg, IL-31096 Haifa, Israel
[2] Rambam Med Ctr, Pathol Lab, IL-31096 Haifa, Israel
[3] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
关键词
Granuloma; Giant cell/drug therapy*; Giant cell/surgery; Adrenal cortex hormones/therapeutic use; Calcitonin/therapeutic use; INTRALESIONAL CORTICOSTEROID INJECTION; CALCITONIN THERAPY; BONE-RESORPTION; OSTEOCLAST FORMATION; LESIONS; TUMOR; INTERFERON; FEATURES;
D O I
10.1016/j.jcms.2011.04.002
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background: The aggressive type lesions of central giant cell granuloma (CGCG) require wide resection that leads to major defects in the jaws. This form of surgical treatment can be particularly disfiguring. A number of alternative non-surgical therapies have been advocated in recent years for the management of the central giant cell granuloma (CGCG). These include calcitonin injections and nasal spray, intralesional steroid injections and subcutaneous interferon injections. Materials and methods: A large central giant cell granuloma aggressive type lesion in the mandible of a 24-year-old patient was treated successfully by intralesional injection of corticosteroid and nasal spray calcitonin that was followed by curettage with peripheral ostectomy with preservation of the continuity of the mandible and the teeth. At the 5-year clinical and radiological follow up there was no sign of recurrence. Conclusions: This combined medical and surgical treatment is advantageous for large aggressive lesions in order to reduce the size of the lesion and thus minimize the need for extensive bone resection and loss of teeth that can result in functional and aesthetic defects. (C) 2011 European Association for Cranio-Maxillo-Facial Surgery.
引用
收藏
页码:292 / 297
页数:6
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