Pityriasis Rubra Pilaris: Treatment with Biologics - A New Promising Therapy?

被引：20

作者：

Ivanova, Katja ^{[1
]}

Itin, Peter ^{[1
]}

Haeusermann, Peter ^{[1
]}

机构：

[1] Univ Basel Hosp, Dept Dermatol, CH-4031 Basel, Switzerland

来源：

DERMATOLOGY | 2012年 / 224卷 / 02期

关键词：

Pityriasis rubra pilaris; Biological agents; Tumor necrosis factor; VITAMIN-A; ALPHA; MANIFESTATION; INFLIXIMAB;

D O I：

10.1159/000337546

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Pityriasis rubra pilaris (PRP) includes a spectrum of rare chronic inflammatory disorders with papulosquamous eruptions of unknown cause. Different etiologies have been proposed such as vitamin A metabolism dysfunction, association with autoimmune disorders, infection or malignancies. However, PRP seems to be a polygenic skin disorder. Classical systemic treatment is empirical and includes retinoids and methotrexate; however, only few series on treatments exist. Recently there has been an increasing number of reports documenting that new biologicals and in particular TNF-alpha blockers are safe and effective. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：120 / 125

页数：6

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